ReviewCurrent pharmaceutical design2014
Multiple hormonal dysregulation as determinant of low physical performance and mobility in older persons.
Review in Current pharmaceutical design, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Growth Hormone and Brain Regeneration: Evidence from Clinical Studies in Dementia, Traumatic Brain Injury, and Stroke: A Systematic Review.International journal of molecular sciences · 2026Pooled it
- Effects of Vitamin D on Physical Function: Results From the STURDY Trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Trial
- Modified cardiometabolic index outperforms conventional indices in discriminating relative muscle loss: a cross-sectional analysis of NHANES 2011-2018.European journal of medical research · 2026Article
- Beyond adrenal fatigue: reframing the adrenal stress index through neutrophil-mediated glucocorticoid resistance.Frontiers in endocrinology · 2026Review
- The treatment of chronic anemia in heart failure: a global approach.Clinical research in cardiology : official journal of the German Cardiac Society · 2024Review
- Aquatic Exercise Positively Affects Physiological Frailty among Postmenopausal Women: A Randomized Controlled Clinical Trial.Healthcare (Basel, Switzerland) · 2021Article
- Frailty subtypes and recovery in older survivors of acute respiratory failure: a pilot study.Thorax · 2021Article
- Critical Illness and the Frailty Syndrome: Mechanisms and Potential Therapeutic Targets.Anesthesia and analgesia · 2020Review
- Comprehensive Model for Physical and Cognitive Frailty: Current Organization and Unmet Needs.Frontiers in psychology · 2020Review
- Article
- Stress-related hormones in association with periodontal condition in adolescents-results of the epidemiologic LIFE Child study.Clinical oral investigations · 2019Article
- DHEA Treatment Effects on Redox Environment in Skeletal Muscle of Young and Aged Healthy Rats.Current aging science · 2018Article
- Age-Related Change in Mobility: Perspectives From Life Course Epidemiology and Geroscience.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016Review
- The effects of strength training on cognitive performance in elderly women.Clinical interventions in aging · 2016Article
- Article
- INSULIN-LIKE GROWTH FACTOR-1 AND ANEMIA IN OLDER SUBJECTS: THE INCHIANTI STUDY.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2015Article
- The Role of the Multiple Hormonal Dysregulation in the Onset of "Anemia of Aging": Focus on Testosterone, IGF-1, and Thyroid Hormones.International journal of endocrinology · 2015Review
- The Interplay between Magnesium and Testosterone in Modulating Physical Function in Men.International journal of endocrinology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Mobility-disability is a common condition in older individuals. Many factors, including the age-related hormonal dysregulation, may concur to the development of disability in the elderly. In fact, during the aging process it is observed an imbalance between anabolic hormones that decrease (testosterone, dehydroepiandrosterone sulphate (DHEAS), estradiol, insulin like growth factor-1 (IGF-1) and Vitamin D) and catabolic hormones (cortisol, thyroid hormones) that increase. We start this review focusing on the mechanisms by which anabolic and catabolic hormones may affect physical performance and mobility. To address the role of the hormonal dysregulation to mobility-disability, we start to discuss the contribution of the single hormonal derangement. The studies used in this review were selected according to the period of time of publication, ranging from 2002 to 2013, and the age of the participants (≥65 years). We devoted particular attention to the effects of anabolic hormones (DHEAS, testosterone, estradiol, Vitamin D and IGF-1) on both skeletal muscle mass and strength, as well as other objective indicators of physical performance. We also analyzed the reasons beyond the inconclusive data coming from RCTs using sex hormones, thyroid hormones, and vitamin D (dosage, duration of treatment, baseline hormonal values and reached hormonal levels). We finally hypothesized that the parallel decline of anabolic hormones has a higher impact than a single hormonal derangement on adverse mobility outcomes in older population. Given the multifactorial origin of low mobility, we underlined the need of future synergistic optional treatments (micronutrients and exercise) to improve the effectiveness of hormonal treatment and to safely ameliorate the anabolic hormonal status and mobility in older individuals.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.