ArticleTranslational vision science & technology2012
The Oral Iron Chelator Deferiprone Protects Against Retinal Degeneration Induced through Diverse Mechanisms.
Article in Translational vision science & technology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
5 citing papers in PubMed.
- Exposure of A2E to blue light promotes ferroptosis in the retinal pigment epithelium.Cellular & molecular biology letters · 2025Article
- Deferiprone promoted remyelination and functional recovery through enhancement of oligodendrogenesis in experimental demyelination animal model.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Dexras1 Deletion and Iron Chelation Promote Neuroprotection in Experimental Optic Neuritis.Scientific reports · 2019Article
- Multimodal Fundus Imaging of Sodium Iodate-Treated Mice Informs RPE Susceptibility and Origins of Increased Fundus Autofluorescence.Investigative ophthalmology & visual science · 2017Article
- Take Two Iron Chelators and Call Me in the Morning.Translational vision science & technology · 2012Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
purposeTo investigate the effect of the iron chelator deferiprone (DFP) on sodium iodate (NaIO
methodsRetinas from NaIO
resultsIn NaIO
conclusionsThe oral iron chelator DFP provides significant protection against retinal degeneration induced through different modalities. This suggests that iron chelation could be useful as a treatment for retinal degeneration even when the main etiology does not appear to be iron dysregulation. TRANSLATIONAL RELEVANCE: These data provide proof of principle that the oral iron chelator DFP can protect the retina against diverse insults. Further testing of DFP in additional animal retinal degeneration models at a range of doses is warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.