ArticleBiomedical optics express2013
Enumerating virus-like particles in an optically concentrated suspension by fluorescence correlation spectroscopy.
Article in Biomedical optics express, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Discovery of Therapeutic Antibodies Targeting Complex Multi-Spanning Membrane Proteins.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2024Review
- Digital Twin for Continuous Production of Virus-like Particles toward Autonomous Operation.ACS omega · 2024Article
- Label-free focusing of viral particles under a temperature gradient coupled with continuous swirling flow.RSC advances · 2022Article
- At-line multi-angle light scattering detector for faster process development in enveloped virus-like particle purification.Journal of separation science · 2019Article
- Tangential Flow Microfiltration for Viral Separation and Concentration.Micromachines · 2019Article
- Micropatterned macroporous structures in microfluidic devices for viral separation from whole blood.The Analyst · 2017Article
- Microfluidic devices with templated regular macroporous structures for HIV viral capture.The Analyst · 2016Article
- Introduction: Optical trapping and applications feature issue.Biomedical optics express · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Fluorescence correlation spectroscopy (FCS) is one of the most sensitive methods for enumerating low concentration nanoparticles in a suspension. However, biological nanoparticles such as viruses often exist at a concentration much lower than the FCS detection limit. While optically generated trapping potentials are shown to effectively enhance the concentration of nanoparticles, feasibility of FCS for enumerating field-enriched nanoparticles requires understanding of the nanoparticle behavior in the external field. This paper reports an experimental study that combines optical trapping and FCS to examine existing theoretical predictions of particle concentration. Colloidal suspensions of polystyrene (PS) nanospheres and HIV-1 virus-like particles are used as model systems. Optical trapping energies and statistical analysis are used to discuss the applicability of FCS for enumerating nanoparticles in a potential well produced by a force field.
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Registered trials
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