ArticleBiomedical optics express2013
Optical pacing of the adult rabbit heart.
Article in Biomedical optics express, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04601337 (Clinical Safety and Efficacy of Infrared Neural Stimulation During Nerve Transfers), which is not on this map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Safety and Efficacy of Infrared Neural Stimulation During Nerve Transfers
Who cites it
35 citing papers in PubMed.
- Magnetically gated millimeter-scale capsule power system for leadless electrotherapy.Science advances · 2026Article
- Therapeutic Potential of Infrared and Related Light Therapies in Metabolic Diseases.International journal of molecular sciences · 2025Review
- Infrared neuroglial modulation of spinal locomotor networks.Scientific reports · 2024Article
- Nongenetic Optical Modulation of Pluripotent Stem Cells Derived Cardiomyocytes Function in the Red Spectral Range.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Emerging trends in the development of flexible optrode arrays for electrophysiology.APL bioengineering · 2023Review
- Infrared neural stimulation markedly enhances nerve functionality assessment during nerve monitoring.Scientific reports · 2023Article
- Histological and electrophysiological evidence on the safe operation of a sharp-tip multimodal optrode during infrared neuromodulation of the rat cortex.Scientific reports · 2022Article
- Porosity-based heterojunctions enable leadless optoelectronic modulation of tissues.Nature materials · 2022Article
- Optical neural stimulation using the thermoplasmonic effect of gold nano-hexagon.Biomedical optics express · 2021Article
- Micelle-enabled self-assembly of porous and monolithic carbon membranes for bioelectronic interfaces.Nature nanotechnology · 2021Article
- Identifying optimal parameters for infrared neural stimulation in the peripheral nervous system.Neurophotonics · 2021Article
- Optical stimulation of neural tissue.Healthcare technology letters · 2020Article
- Nano-enabled cellular engineering for bioelectric studies.Nano research · 2020Article
- Multiphoton intravital microscopy in small animals: motion artefact challenges and technical solutions.Journal of microscopy · 2020Review
- Near-infrared light driven tissue-penetrating cardiac optogenetics via upconversion nanoparticles in vivo.Biomedical optics express · 2020Article
- Infrared neural stimulation and inhibition using an implantable silicon photonic microdevice.Microsystems & nanoengineering · 2020Article
- Feasibility of Using Adjunctive Optogenetic Technologies in Cardiomyocyte Phenotyping - from the Single Cell to the Whole Heart.Current pharmaceutical biotechnology · 2020Review
- Influence of radiant exposure and repetition rate in infrared neural stimulation with near-infrared lasers.Lasers in medical science · 2019Article
- Thermal block of action potentials is primarily due to voltage-dependent potassium currents: a modeling study.Journal of neural engineering · 2019Article
- Optical stimulation of cardiac cells with a polymer-supported silicon nanowire matrix.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Optical pacing has been demonstrated to be a viable alternative to electrical pacing in embryonic hearts. In this study, the feasibility of optically pacing an adult rabbit heart was explored. Hearts from adult New Zealand White rabbits (n = 9) were excised, cannulated and perfused on a modified Langendorff apparatus. Pulsed laser light (λ = 1851 nm) was directed to either the left or right atrium through a multimode optical fiber. An ECG signal from the left ventricle and a trigger pulse from the laser were recorded simultaneously to determine when capture was achieved. Successful optical pacing was demonstrated by obtaining pacing capture, stopping, then recapturing as well as by varying the pacing frequency. Stimulation thresholds measured at various pulse durations suggested that longer pulses (8 ms) had a lower energy capture threshold. To determine whether optical pacing caused damage, two hearts were perfused with 30 µM of propidium iodide and analyzed histologically. A small number of cells near the stimulation site had compromised cell membranes, which probably limited the time duration over which pacing was maintained. Here, short-term optical pacing (few minutes duration) is demonstrated in the adult rabbit heart for the first time. Future studies will be directed to optimize optical pacing parameters to decrease stimulation thresholds and may enable longer-term pacing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.