ArticleJournal of virology2013
Murine norovirus transcytosis across an in vitro polarized murine intestinal epithelial monolayer is mediated by M-like cells.
Article in Journal of virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 47 citations in OpenAlex.
- Amino acid substitutions in norovirus VP1 dictate host dissemination via variations in cellular attachment.Journal of virology · 2023Article
- Mouse Norovirus Uses Host Metabolites to Enhance Receptor Binding and Evade Immune Recognition.Medical research archives · 2022Article
- Immunity to enteric viruses.Immunity · 2022Review
- Bacterial extracellular vesicles control murine norovirus infection through modulation of antiviral immune responses.Frontiers in immunology · 2022Article
- MyD88 Mediates Colitis- and RANKL-Induced Microfold Cell Differentiation.Veterinary sciences · 2021Article
- Mother-to-Child Transmission of Arboviruses during Breastfeeding: From Epidemiology to Cellular Mechanisms.Viruses · 2021Review
- Transcytosis of Bacillus subtilis extracellular vesicles through an in vitro intestinal epithelial cell model.Scientific reports · 2020Article
- Evidence That Zika Virus Is Transmitted by Breastfeeding to Newborn A129 (Frontiers in microbiology · 2020Article
- Natural Secretory Immunoglobulins Promote Enteric Viral Infections.Journal of virology · 2018Article
- Targeting macrophage- and intestinal epithelial cell-specific microRNAs against norovirus restricts replication in vivo.The Journal of general virology · 2018Article
- Persistence of Systemic Murine Norovirus Is Maintained by Inflammatory Recruitment of Susceptible Myeloid Cells.Cell host & microbe · 2018Article
- The Role of Interferon in Persistent Viral Infection: Insights from Murine Norovirus.Trends in microbiology · 2018Review
- The major targets of acute norovirus infection are immune cells in the gut-associated lymphoid tissue.Nature microbiology · 2017Article
- Norovirus Cell Tropism Is Determined by Combinatorial Action of a Viral Non-structural Protein and Host Cytokine.Cell host & microbe · 2017Article
- A human intestinal M-cell-like model for investigating particle, antigen and microorganism translocation.Nature protocols · 2017Article
- Recent advances in understanding noroviruses.F1000Research · 2017Review
- Norovirus Regulation by Host and Microbe.Trends in molecular medicine · 2016Review
- Recent advances in understanding norovirus pathogenesis.Journal of medical virology · 2016Review
- Replication of Human Norovirus RNA in Mammalian Cells Reveals Lack of Interferon Response.Journal of virology · 2016Article
- The influence of commensal bacteria on infection with enteric viruses.Nature reviews. Microbiology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Noroviruses (NoVs) are the causative agent of the vast majority of nonbacterial gastroenteritis worldwide. Due to the inability to culture human NoVs and the inability to orally infect a small animal model, little is known about the initial steps of viral entry. One particular step that is not understood is how NoVs breach the intestinal epithelial barrier. Murine NoV (MNV) is the only NoV that can be propagated in vitro by infecting murine macrophages and dendritic cells, making this virus an attractive model for studies of different aspects of NoV biology. Polarized murine intestinal epithelial mICcl2 cells were used to investigate how MNV interacts with and crosses the intestinal epithelium. In this in vitro model of the follicle-associated epithelium (FAE), MNV is transported across the polarized cell monolayer in the absence of viral replication or disruption of tight junctions by a distinct epithelial cell with microfold (M) cell properties. In addition to transporting MNV, these M-like cells also transcytose microbeads and express an IgA receptor. Interestingly, B myeloma cells cultured in the basolateral compartment underlying the epithelial monolayer did not alter the number of M-like cells but increased their transcytotic activity. Our data demonstrate that MNV can cross an intact intestinal epithelial monolayer in vitro by hijacking the M-like cells' intrinsic transcytotic pathway and suggest a potential mechanism for MNV entry into the host.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.