ArticleNucleic acids research2014
A novel route to product specificity in the Suv4-20 family of histone H4K20 methyltransferases.
Article in Nucleic acids research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Functional Analyses of Histone Methyltransferases in Sea Lamprey Embryos Undergoing Programmed DNA Elimination.bioRxiv : the preprint server for biology · 2026Article
- Review
- Semisynthesis of Isomerized Histone H4 Reveals Robustness and Vulnerability of Chromatin toward Molecular Aging.Journal of the American Chemical Society · 2025Article
- Article
- Knockout mice with pituitary malformations help identify human cases of hypopituitarism.Genome medicine · 2024Article
- NovelHeliyon · 2024Article
- Impact of Histone Lysine Methyltransferase SUV4-20H2 on Cancer Onset and Progression with Therapeutic Potential.International journal of molecular sciences · 2024Review
- Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1.bioRxiv : the preprint server for biology · 2023Article
- Article
- Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease.Nature reviews. Drug discovery · 2021Review
- Structural basis of nucleosomal histone H4 lysine 20 methylation by SET8 methyltransferase.Life science alliance · 2021Article
- Review
- Review
- H3K9me3 and H4K20me3 represent the epigenetic landscape for 53BP1 binding to DNA lesions.Aging · 2018Article
- Understanding the Histone DNA Repair Code: H4K20me2 Makes Its Mark.Molecular cancer research : MCR · 2018Review
- The histone H4 proteoform dynamics in response to SUV4-20 inhibition reveals single molecule mechanisms of inhibitor resistance.Epigenetics & chromatin · 2018Article
- Histone H4 Methyltransferase Suv420h2 Maintains Fidelity of Osteoblast Differentiation.Journal of cellular biochemistry · 2017Article
- Writing, erasing and reading histone lysine methylations.Experimental & molecular medicine · 2017Review
- A histone H4 lysine 20 methyltransferase couples environmental cues to sensory neuron control of developmental plasticity.Development (Cambridge, England) · 2017Article
- SUV4-20 activity in the preimplantation mouse embryo controls timely replication.Genes & development · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The delivery of site-specific post-translational modifications to histones generates an epigenetic regulatory network that directs fundamental DNA-mediated processes and governs key stages in development. Methylation of histone H4 lysine-20 has been implicated in DNA repair, transcriptional silencing, genomic stability and regulation of replication. We present the structure of the histone H4K20 methyltransferase Suv4-20h2 in complex with its histone H4 peptide substrate and S-adenosyl methionine cofactor. Analysis of the structure reveals that the Suv4-20h2 active site diverges from the canonical SET domain configuration and generates a high degree of both substrate and product specificity. Together with supporting biochemical data comparing Suv4-20h1 and Suv4-20h2, we demonstrate that the Suv4-20 family enzymes take a previously mono-methylated H4K20 substrate and generate an exclusively di-methylated product. We therefore predict that other enzymes are responsible for the tri-methylation of histone H4K20 that marks silenced heterochromatin.
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