ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Persistent activity in prefrontal cortex during trace eyelid conditioning: dissociating responses that reflect cerebellar output from those that do not.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed, 47 citations in OpenAlex.
- The Timing of Attentional Distraction Matters in Facilitating Extinction of Trace Fear Memory.Experimental neurobiology · 2026Article
- Fast implicit and slow explicit learning of temporal context.Scientific reports · 2025Article
- Neuronal dynamics of cerebellum and medial prefrontal cortex in adaptive motor timing.Nature communications · 2025Article
- The Role of Cerebellar Intrinsic Neuronal Excitability, Synaptic Plasticity, and Perineuronal Nets in Eyeblink Conditioning.Biology · 2024Review
- Dynamic Changes in Local Activity and Network Interactions among the Anterior Cingulate, Amygdala, and Cerebellum during Associative Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The cerebellum regulates fear extinction through thalamo-prefrontal cortex interactions in male mice.Nature communications · 2023Article
- Prefrontal projections to the nucleus reuniens signal behavioral relevance of stimuli during associative learning.Scientific reports · 2022Article
- Ventromedial Thalamus-Projecting DCN Neurons Modulate Associative Sensorimotor Responses in Mice.Neuroscience bulletin · 2022Article
- Functional properties of eyelid conditioned responses and involved brain centers.Frontiers in behavioral neuroscience · 2022Review
- Hippocampal Interneurons are Required for Trace Eyeblink Conditioning in Mice.Neuroscience bulletin · 2021Article
- The Claustrum is Involved in Cognitive Processes Related to the Classical Conditioning of Eyelid Responses in Behaving Rabbits.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Population coding in the cerebellum: a machine learning perspective.Journal of neurophysiology · 2020Review
- Hippocampal and lateral entorhinal cortex physiological activity during trace conditioning under urethane anesthesia.Journal of neurophysiology · 2020Article
- Review
- Distributed representations of temporal stimulus associations across regular-firing and fast-spiking neurons in rat medial prefrontal cortex.Journal of neurophysiology · 2020Article
- Changes in cerebellar intrinsic neuronal excitability and synaptic plasticity result from eyeblink conditioning.Neurobiology of learning and memory · 2019Review
- Article
- Reevaluating the ability of cerebellum in associative motor learning.Scientific reports · 2019Article
- Article
- Medial Prefrontal Cortex-Pontine Nuclei Projections Modulate Suboptimal Cue-Induced Associative Motor Learning.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
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2 authors at 2 institutions in 1 country.
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Abstract
Persistent neural activity, responses that outlast the stimuli that evoke them, plays an important role in neural computations and possibly in processes, such as working memory. Recent studies suggest that trace eyelid conditioning, which involves a temporal gap between the conditioned and unconditioned stimuli (the trace interval), requires persistent neural activity in a region of medial prefrontal cortex (mPFC). This persistent activity, which could be conveyed to cerebellum via a pathway through pons, may engage the cerebellum and allow for the expression of conditioned responses. Given the substantial reciprocity observed among many brain regions, it is essential to demonstrate that persistent responses in mPFC neurons are not simply a reflection of cerebellar feedback to the forebrain, leaving open the possibility that such responses could serve as input to the cerebellum. This concern is highlighted by studies showing that hippocampal learning-related activity is abolished by cerebellar inactivation. We inactivated the cerebellum while recording single-unit activity from the mPFC of rabbits trained with a forebrain-dependent trace eyelid conditioning procedure. We report that, whereas the responses of cells that show an onset of increased spike activity during the trace interval were abolished by cerebellar inactivation, persistent responses that begin during the conditioned stimulus and persisted into the trace interval were unaffected. Therefore, conditioned stimulus-evoked persistent responses remain the strongest candidate input pattern to support the cerebellar expression of learned responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.