ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
The role of GluA1 in ocular dominance plasticity in the mouse visual cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- TNF-dependent regulation of synaptic plasticity and neuronal activity: implications for psychiatric disorders.Molecular psychiatry · 2026Review
- Limiting Hearing Loss in Transgenic Mouse Models.eNeuro · 2025Article
- Blockade of GluN2B-Containing NMDA Receptors Prevents Potentiation and Depression of Responses during Ocular Dominance Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- High Magnesium Promotes the Recovery of Binocular Vision from Amblyopia via TRPM7.Neuroscience bulletin · 2024Article
- Investigating female versus male differences in white matter neuroplasticity associated with complex visuo-motor learning.Scientific reports · 2024Article
- Recruitment of frontal sensory circuits during visual discrimination.Cell reports · 2022Article
- Closing the Critical Period Is Required for the Maturation of Binocular Integration in Mouse Primary Visual Cortex.Frontiers in cellular neuroscience · 2021Article
- Distinct Laminar Requirements for NMDA Receptors in Experience-Dependent Visual Cortical Plasticity.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Top-Down Suppression of Sensory Cortex in an NMDAR Hypofunction Model of Psychosis.Schizophrenia bulletin · 2019Article
- Mechanisms underlying the role of DISC1 in synaptic plasticity.The Journal of physiology · 2018Review
- Article
- Major Vault Protein, a Candidate Gene in 16p11.2 Microdeletion Syndrome, Is Required for the Homeostatic Regulation of Visual Cortical Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Visual experience sculpts whole-cortex spontaneous infraslow activity patterns through an Arc-dependent mechanism.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Article
- Do cortical plasticity mechanisms differ between males and females?Journal of neuroscience research · 2017Review
- Astrocyte and Neuronal Plasticity in the Somatosensory System.Neural plasticity · 2015Review
- STAT1 regulates the homeostatic component of visual cortical plasticity via an AMPA receptor-mediated mechanism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Mouse vision as a gateway for understanding how experience shapes neural circuits.Frontiers in neural circuits · 2014Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Ocular dominance plasticity is a widely studied model of experience-dependent cortical plasticity. It has been shown that potentiation of open eye responses resulting from monocular deprivation relies on a homeostatic response to loss of input from the closed eye, but the mechanisms by which this occurs are not fully understood. The role of GluA1 in the homeostatic component of ocular dominance (OD) plasticity has not so far been tested. In this study, we tested the idea that the GluA1 subunit of the AMPA receptor is necessary for open eye potentiation. We found that open eye potentiation did not occur in GluA1 knock-out (GluA1(-/-)) mice but did occur in wild-type littermates when monocular deprivation was imposed during the critical period. We also found that depression of the closed eye response that normally occurs in the monocular as well as binocular zone is delayed, but only in the monocular zone in GluA1(-/-) mice and only in a background strain we have previously shown lacks synaptic scaling (C57BL/6OlaHsd). In adult mice, we found that OD plasticity and facilitation of OD plasticity by prior monocular experience were both present in GluA1(-/-) mice, suggesting that the GluA1-dependent mechanisms only operate during the critical period.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.