ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Dendrite complexity of sympathetic neurons is controlled during postnatal development by BMP signaling.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Molecular and cellular neurocardiology in heart disease.The Journal of physiology · 2025Review
- Ketamine's rapid and sustained antidepressant effects are driven by distinct mechanisms.Cellular and molecular life sciences : CMLS · 2024Article
- Ischemia-reperfusion myocardial infarction induces remodeling of left cardiac-projecting stellate ganglia neurons.American journal of physiology. Heart and circulatory physiology · 2024Article
- Gamma secretase activity modulates BMP-7-induced dendritic growth in primary rat sympathetic neurons.Autonomic neuroscience : basic & clinical · 2023Article
- Regulation of Tau Expression in Superior Cervical Ganglion (SCG) Neurons In Vivo and In Vitro.Cells · 2023Article
- The sympathetic nervous system in development and disease.Nature reviews. Neuroscience · 2021Review
- A low affinityeLife · 2020Article
- Association of distinct type 1 bone morphogenetic protein receptors with different molecular pathways and survival outcomes in neuroblastoma.Neuronal signaling · 2020Article
- Inactive matrix gla protein plasma levels are associated with peripheral neuropathy in Type 2 diabetes.PloS one · 2020Article
- Coiled-coil structure-dependent interactions between polyQ proteins and Foxo lead to dendrite pathology and behavioral defects.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Sympathetic tales: subdivisons of the autonomic nervous system and the impact of developmental studies.Neural development · 2018Review
- Retrogradely Transported TrkA Endosomes Signal Locally within Dendrites to Maintain Sympathetic Neuron Synapses.Cell reports · 2017Article
- BMP7-induced dendritic growth in sympathetic neurons requires p75(NTR) signaling.Developmental neurobiology · 2016Article
- Lin28B and Let-7 in the Control of Sympathetic Neurogenesis and Neuroblastoma Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Regulation of dendrite morphogenesis by extrinsic cues.Trends in neurosciences · 2015Review
- Reactive oxygen species are involved in BMP-induced dendritic growth in cultured rat sympathetic neurons.Molecular and cellular neurosciences · 2015Article
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Authors and funding
10 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dendrite development is controlled by the interplay of intrinsic and extrinsic signals affecting initiation, growth, and maintenance of complex dendrites. Bone morphogenetic proteins (BMPs) stimulate dendrite growth in cultures of sympathetic, cortical, and hippocampal neurons but it was unclear whether BMPs control dendrite morphology in vivo. Using a conditional knock-out strategy to eliminate Bmpr1a and Smad4 in immature noradrenergic sympathetic neurons we now show that dendrite length, complexity, and neuron cell body size are reduced in adult mice deficient of Bmpr1a. The combined deletion of Bmpr1a and Bmpr1b causes no further decrease in dendritic features. Sympathetic neurons devoid of Bmpr1a/1b display normal Smad1/5/8 phosphorylation, which suggests that Smad-independent signaling paths are involved in dendritic growth control downstream of BMPR1A/B. Indeed, in the Smad4 conditional knock-out dendrite and cell body size are not affected and dendrite complexity and number are increased. Together, these results demonstrate an in vivo function for BMPs in the generation of mature sympathetic neuron dendrites. BMPR1 signaling controls dendrite complexity postnatally during the major dendritic growth period of sympathetic neurons.
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