ArticleDigestive diseases and sciences2014
Characterization of hepatocellular carcinoma related genes and metabolites in human nonalcoholic fatty liver disease.
Article in Digestive diseases and sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 44 citations in OpenAlex.
- Discriminatory Changes in Circulating Metabolites as a Predictor of Hepatocellular Cancer in Patients with Metabolic (Dysfunction) Associated Fatty Liver Disease.Liver cancer · 2023Article
- The Emerging Role of Circular RNA Homeodomain Interacting Protein Kinase 3 and Circular RNA 0046367 through Wnt/Beta-Catenin Pathway on the Pathogenesis of Nonalcoholic Steatohepatitis in Egyptian Patients.Reports of biochemistry & molecular biology · 2023Article
- Epidemiologic, Genetic, Pathogenic, Metabolic, Epigenetic Aspects Involved in NASH-HCC: Current Therapeutic Strategies.Cancers · 2022Review
- Modelling Nonalcoholic Steatohepatitis In Vivo-A Close Transcriptomic Similarity Supports the Guinea Pig Disease Model.Biomedicines · 2021Article
- Recent Advances of Microbiome-Associated Metabolomics Profiling in Liver Disease: Principles, Mechanisms, and Applications.International journal of molecular sciences · 2021Review
- Relevance of VEGFA in rat livers subjected to partial hepatectomy under ischemia-reperfusion.Journal of molecular medicine (Berlin, Germany) · 2019Article
- Hepatocellular carcinoma and metabolic syndrome: The times are changing and so should we.World journal of gastroenterology · 2019Article
- Metabolic control of gene transcription in non-alcoholic fatty liver disease: the role of the epigenome.Clinical epigenetics · 2019Review
- Effect of Aerobic Exercise on Serum Metabolites in Mice with Hepatocellular Carcinoma After Surgery.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Dietary cholesterol promotes steatohepatitis related hepatocellular carcinoma through dysregulated metabolism and calcium signaling.Nature communications · 2018Article
- Interspecies NASH disease activity whole-genome profiling identifies a fibrogenic role of PPARα-regulated dermatopontin.JCI insight · 2017Article
- UPLC-MS for metabolomics: a giant step forward in support of pharmaceutical research.Drug discovery today · 2017Review
- Hepatocellular carcinoma and non-alcoholic steatohepatitis: The state of play.World journal of gastroenterology · 2016Review
- Increased Circulating Levels of Alpha-Ketoglutarate in Morbidly Obese Women with Non-Alcoholic Fatty Liver Disease.PloS one · 2016Article
- The Subtle Balance between Lipolysis and Lipogenesis: A Critical Point in Metabolic Homeostasis.Nutrients · 2015Review
- β-catenin alteration is rare in hepatocellular carcinoma with steatohepatitic features: immunohistochemical and mutational study.Virchows Archiv : an international journal of pathology · 2015Article
- From nonalcoholic Fatty liver disease to hepatocellular carcinoma: a systems understanding.Digestive diseases and sciences · 2014Article
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11 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundThe worldwide prevalences of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are estimated to range from 30 to 40 % and 5-17 %, respectively. Hepatocellular carcinoma (HCC) is primarily caused by hepatitis B infection, but retrospective data suggest that 4-29 % of NASH cases will progress to HCC. Currently the connection between NASH and HCC is unclear.
aimsThe purpose of this study was to identify changes in expression of HCC-related genes and metabolite profiles in NAFLD progression.
methodsTranscriptomic and metabolomic datasets from human liver tissue representing NAFLD progression (normal, steatosis, NASH) were utilized and compared to published data for HCC.
resultsGenes involved in Wnt signaling were downregulated in NASH but have been reported to be upregulated in HCC. Extracellular matrix/angiogenesis genes were upregulated in NASH, similar to reports in HCC. Iron homeostasis is known to be perturbed in HCC and we observed downregulation of genes in this pathway. In the metabolomics analysis of hepatic NAFLD samples, several changes were opposite to what has been reported in plasma of HCC patients (lysine, phenylalanine, citrulline, creatine, creatinine, glycodeoxycholic acid, inosine, and alpha-ketoglutarate). In contrast, multiple acyl-lyso-phosphatidylcholine metabolites were downregulated in NASH livers, consistent with observations in HCC patient plasma.
conclusionsThese data indicate an overlap in the pathogenesis of NAFLD and HCC where several classes of HCC related genes and metabolites are altered in NAFLD. Importantly, Wnt signaling and several metabolites are different, thus implicating these genes and metabolites as mediators in the transition from NASH to HCC.
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