ArticleInfection and immunity1990
Caveats in the investigation of form-specific molecules of Candida albicans.
Article in Infection and immunity, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Contribution of phospholipomannan to the surface expression of beta-1,2-oligomannosides in Candida albicans and its presence in cell wall extracts.Infection and immunity · 2002Article
- Low levels of antigenic variability in fluconazole-susceptible and -resistant Candida albicans isolates from human immunodeficiency virus-infected patients with oropharyngeal candidiasis.Clinical and diagnostic laboratory immunology · 1999Article
- Cell wall and secreted proteins of Candida albicans: identification, function, and expression.Microbiology and molecular biology reviews : MMBR · 1998Review
- Common and form-specific cell wall antigens of Candida albicans as released by chemical and enzymatic treatments.Mycopathologia · 1996Article
- Re-expression by Candida albicans germ tubes of antigens lost during subculture of blastospores.Mycopathologia · 1996Article
- Differential susceptibility of yeast and hyphal forms of Candida albicans to proteolytic activity of macrophages.Infection and immunity · 1995Article
- Modulation of cell surface-associated mannoprotein antigen expression in experimental candidal vaginitis.Infection and immunity · 1994Article
- Characterization of Candida albicans cell wall antigens with monoclonal antibodies.Infection and immunity · 1993Article
- Cloning and characterization of ECE1, a gene expressed in association with cell elongation of the dimorphic pathogen Candida albicans.Infection and immunity · 1993Article
- Characterization of cell wall proteins from yeast and mycelial cells of Candida albicans by labelling with biotin: comparison with other techniques.Infection and immunity · 1992Article
- Mapping of Candida albicans oligomannosidic epitopes by using monoclonal antibodies.Infection and immunity · 1992Article
- Identification of antigens reacting with anti-Candida albicans germ tube antibodies.European journal of epidemiology · 1992Article
- Cytological immunodetection of yeast glycoprotein secretion.European journal of epidemiology · 1992Review
- Adherence and receptor relationships of Candida albicans.Microbiological reviews · 1991Review
- Altered hepatic clearance and killing of Candida albicans in the isolated perfused mouse liver model.Infection and immunity · 1990Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Numerous reports purporting the existence of form-specific antigens of Candida albicans have been published, but it is generally unclear whether antigenic variability is an acceptable alternative interpretation. In this study, we used indirect immunofluorescence and immunogold electron microscopy to determine the distribution and form specificities of two antigens during yeast and hyphal growth in several defined and complex media. The results confirmed that antigen expression varies with length of incubation, nutrition, and serotype and indicate that the form specificities of antigens may be misinterpreted when conclusions are based exclusively on indirect immunofluorescence and extraction procedures. We therefore suggest that investigations be designed to include serotype A and B isolates grown in both complex and chemically defined media and that agglutination, immunofluorescence, or enzyme-linked immunosorbent assays on whole cells or cell extracts be used as presumptive tests. Confirmation of form-specific antigens should be done by appropriate immunoelectron microscopic evaluation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.