ArticleG3 (Bethesda, Md.)2013
Molecular phylogeography of a human autosomal skin color locus under natural selection.
Article in G3 (Bethesda, Md.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Review
- Estimating the age of single nucleotide polymorphic sites in humans.Genes & genomics · 2021Article
- Skin pigmentation polymorphisms associated with increased risk of melanoma in a case-control sample from southern Brazil.BMC cancer · 2020Article
- Adaptation of human skin color in various populations.Hereditas · 2018Review
- Genome-wide data from two early Neolithic East Asian individuals dating to 7700 years ago.Science advances · 2017Article
- Genomic signals of migration and continuity in Britain before the Anglo-Saxons.Nature communications · 2016Article
- Genome scans for detecting footprints of local adaptation using a Bayesian factor model.Molecular biology and evolution · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Divergent natural selection caused by differences in solar exposure has resulted in distinctive variations in skin color between human populations. The derived light skin color allele of the SLC24A5 gene, A111T, predominates in populations of Western Eurasian ancestry. To gain insight into when and where this mutation arose, we defined common haplotypes in the genomic region around SLC24A5 across diverse human populations and deduced phylogenetic relationships between them. Virtually all chromosomes carrying the A111T allele share a single 78-kb haplotype that we call C11, indicating that all instances of this mutation in human populations share a common origin. The C11 haplotype was most likely created by a crossover between two haplotypes, followed by the A111T mutation. The two parental precursor haplotypes are found from East Asia to the Americas but are nearly absent in Africa. The distributions of C11 and its parental haplotypes make it most likely that these two last steps occurred between the Middle East and the Indian subcontinent, with the A111T mutation occurring after the split between the ancestors of Europeans and East Asians.
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Registered trials
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