ArticleBiology of reproduction2013
Expression profiling reveals developmentally regulated lncRNA repertoire in the mouse male germline.
Article in Biology of reproduction, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
47 citing papers in PubMed, 97 citations in OpenAlex.
- Cellular and molecular functions of long noncoding RNAs in testis, aging and diseases.Biogerontology · 2025Review
- Mechanism of LncRNA Gm2044 in germ cell development.Frontiers in cell and developmental biology · 2024Review
- Alterations of mRNA and lncRNA profiles associated with the extracellular matrix and spermatogenesis in goats.Animal bioscience · 2022Article
- Dual regulatory actions of LncBMP4 on BMP4 promote chicken primordial germ cell formation.EMBO reports · 2022Article
- Microinjection of antisense oligonucleotides into living mouse testis enables lncRNA function study.Cell & bioscience · 2021Article
- Integrated Analysis of Long Non-Coding RNA and mRNA Expression Profiles in Testes of Calves and Sexually Mature Wandong Bulls (Animals : an open access journal from MDPI · 2021Article
- H3K4me2 Promotes the Activation of lncCPSET1 by Jun in the Chicken PGC Formation.Animals : an open access journal from MDPI · 2021Article
- Long Noncoding RNAAnimals : an open access journal from MDPI · 2021Article
- Panoramic transcriptome analysis and functional screening of long noncoding RNAs in mouse spermatogenesis.Genome research · 2021Article
- A Novel Meiosis-Related lncRNA, Rbakdn, Contributes to Spermatogenesis by Stabilizing Ptbp2.Frontiers in genetics · 2021Article
- A Testis-Specific Long Noncoding RNA,Frontiers in endocrinology · 2021Article
- Transcriptomics of Meiosis in the Male Mouse.Frontiers in cell and developmental biology · 2021Review
- Long non-coding RNAs (lncRNAs) in spermatogenesis and male infertility.Reproductive biology and endocrinology : RB&E · 2020Review
- Revealing stage-specific expression patterns of long noncoding RNAs along mouse spermatogenesis.RNA biology · 2020Article
- Long noncoding RNAs: new insights in modulating mammalian spermatogenesis.Journal of animal science and biotechnology · 2020Review
- Maternal energy insufficiency affects testicular development of the offspring in a swine model.Scientific reports · 2019Article
- A long noncoding RNA binding to QKI-5 regulates germ cell apoptosis via p38 MAPK signaling pathway.Cell death & disease · 2019Article
- Biological and RNA regulatory function of MOV10 in mammalian germ cells.BMC biology · 2019Article
- A novel testis-specific long noncoding RNA, Tesra, activates the Prss42/Tessp-2 gene during mouse spermatogenesis†.Biology of reproduction · 2019Article
- Genome-wide identification and characterization of long non-coding RNAs during postnatal development of rabbit adipose tissue.Lipids in health and disease · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
In mammals, the transcriptome of large noncoding RNAs (lncRNAs) is believed to be greater than that of messenger RNAs (mRNAs). Some lncRNAs, especially large intergenic noncoding RNAs (lincRNAs), participate in epigenetic regulation by binding chromatin-modifying protein complexes and regulating protein-coding gene expression. Given that epigenetic regulation plays a critical role in male germline development, we embarked on expression profiling of both lncRNAs and mRNAs during male germline reprogramming and postnatal development using microarray analyses. We identified thousands of lncRNAs and hundreds of lincRNAs that are either up- or downregulated at six critical time points during male germ cell development. In addition, highly regulated lncRNAs were correlated with nearby (<30 kb) mRNA gene clusters, which were also significantly up- or downregulated. Large ncRNAs can be localized to both the nucleus and cytoplasm, with nuclear lncRNAs mostly associated with key components of the chromatin-remodeling protein complexes. Our data indicate that expression of lncRNAs is dynamically regulated during male germline development and that lncRNAs may function to regulate gene expression at both transcriptional and posttranscriptional levels via genetic and epigenetic mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.