ArticleJournal of human hypertension2014
Early contribution of arterial wave reflection to left ventricular relaxation abnormalities in a community-dwelling population of normotensive and untreated hypertensive men and women.
Article in Journal of human hypertension, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Recommendations for Improving and Standardizing Vascular Research on Arterial Stiffness: A Scientific Statement From the American Heart Association.Hypertension (Dallas, Tex. : 1979) · 2015Guideline
- The relationship between arterial stiffness and heart failure with preserved ejection fraction: a systemic meta-analysis.Heart failure reviews · 2015Pooled it
- Impact of vascular and cardiac parameters on quality of life in patients undergoing catheter ablation for atrial fibrillation.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Central Blood Pressure and Augmentation Index in Older Adults With Intellectual Disabilities.Journal of intellectual disability research : JIDR · 2025Article
- Hypertensive women with dyspnea exhibit an unfavorable central blood pressure response to exercise.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Association of Aortic Stiffness and Pressure Pulsatility With Noninvasive Estimates of Hepatic Steatosis and Fibrosis: The Framingham Heart Study.Arteriosclerosis, thrombosis, and vascular biology · 2024Article
- Validation of a Suprasystolic Cuff System for Static and Dynamic Representation of the Central Pressure Waveform.Journal of the American Heart Association · 2024Article
- Association of arterial stiffness and heart failure with preserved ejection fraction in the elderly population - results from the CARLA study.Journal of human hypertension · 2023Article
- Aortic stiffness, pressure and flow pulsatility, and target organ damage.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Review
- Deep Phenotyping of Systemic Arterial Hemodynamics in HFpEF (Part 2): Clinical and Therapeutic Considerations.Journal of cardiovascular translational research · 2017Review
- Arterial Stiffness and Risk of Overall Heart Failure, Heart Failure With Preserved Ejection Fraction, and Heart Failure With Reduced Ejection Fraction: The Health ABC Study (Health, Aging, and Body Composition).Hypertension (Dallas, Tex. : 1979) · 2017Article
- Normal age-related changes in left ventricular function: Role of afterload and subendocardial dysfunction.International journal of cardiology · 2016Article
- Abdominal obesity and hypertension: a double burden to the heart.Hypertension research : official journal of the Japanese Society of Hypertension · 2016Article
- The association between sleep-disordered breathing and aortic stiffness in a community cohort.Sleep medicine · 2016Observational
- From Arterial Stiffness to Heart Failure: Still a Long Way to Go.Journal of the American Heart Association · 2015Article
- Sex determines cardiovascular hemodynamics in hypertension.Journal of human hypertension · 2015Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
We examined the contribution of arterial wave reflection to early abnormalities in left ventricular relaxation, whether this association was modified by gender or hypertension and the role of reflected wave timing and amplitude. We studied a cohort of normotensive and untreated essential hypertensive Taiwanese participants (675 men, 601 women, mean age 52 years). Doppler flow and applanation tonometry were performed to assess carotid-femoral pulse wave velocity (PWV) and augmentation index (AI). Diastolic parameters including the ratio between the peak velocity of early and late diastolic mitral inflow (E/A), E-deceleration time and left atrial (LA) diameter were measured by echocardiography. In multivariate models predicting E/A, women were more likely to have lower E/A than men (β=-0.08, P<0.001). AI was significantly associated with lower E/A in both men (β=-0.09, P=0.005) and women (β=-0.12, P<0.001) independent of PWV. Inclusion of AI in the overall model reduced the gender difference in E/A by 61% and rendered it nonsignificant. There was a significant interaction between AI and hypertension (P=0.02). The inverse association between AI and E/A was significant only in normotensive men and women, and only for the amplitude but not timing of the reflected wave. In conclusion, the contribution of wave reflection to left ventricular diastolic dysfunction was independent of arterial stiffness, more pronounced in normotensive individuals and explained a significant portion of the gender difference in diastolic function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.