ArticleMolecules (Basel, Switzerland)2013
Effect of tomato industrial processing on phenolic profile and antiplatelet activity.
Article in Molecules (Basel, Switzerland), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of a Tomato Pomace Extract for Inhibiting Platelet Aggregation
Antiplatlet Effects of Standardized Tomato Extract in Hypertensive Subjects at High Estimated Cardiovascular Risk
Who cites it
25 citing papers in PubMed, 50 citations in OpenAlex.
- Vascular and Platelet Effects of Tomato Soffritto Intake in Overweight and Obese Subjects.Nutrients · 2023Trial
- Chemical Characterization and Antiplatelet Potential of Bioactive Extract from Tomato Pomace (Byproduct of Tomato Paste).Nutrients · 2019Trial
- Tomato Processing By-Products as a Sustainable Source of Lycopene and Other Bioactive Compounds for Animal Nutrition: A Circular-Economy Perspective.Molecules (Basel, Switzerland) · 2026Review
- Diuretic activity of hydro-alcoholic extract and solvent fractions of Solanum lycopersicum L. leaves in mice.Scientific reports · 2025Article
- A step forward in enhancing the health-promoting properties of whole tomato as a functional food to lower the impact of non-communicable diseases.Frontiers in nutrition · 2025Review
- Tomato Residue Management from a Biorefinery Perspective and towards a Circular Economy.Foods (Basel, Switzerland) · 2024Review
- Natural Phenolic Compounds with Antithrombotic and Antiplatelet Effects: A Drug-likeness Approach.Current medicinal chemistry · 2024Review
- Mei-Gin Formula Ameliorates Obesity through Lipolysis, Fatty Oxidation, and Thermogenesis in High-Fat Diet-Induced Obese Rats.Foods (Basel, Switzerland) · 2023Article
- Food Polyphenols and Type II Diabetes Mellitus: Pharmacology and Mechanisms.Molecules (Basel, Switzerland) · 2023Review
- Effects of Extraction Methods on Phenolic Content, Antioxidant and Antiplatelet Activities of Tomato Pomace Extracts.Plants (Basel, Switzerland) · 2023Article
- A Comprehensive Literature Review on Cardioprotective Effects of Bioactive Compounds Present in Fruits ofMolecules (Basel, Switzerland) · 2022Review
- Role ofPlants (Basel, Switzerland) · 2022Review
- Impacts of Commonly Used Edible Plants on the Modulation of Platelet Function.International journal of molecular sciences · 2022Review
- Scientometric and Methodological Analysis of the Recent Literature on the Health-Related Effects of Tomato and Tomato Products.Foods (Basel, Switzerland) · 2021Review
- Diets and Cellular-Derived Microparticles: Weighing a Plausible Link With Cerebral Small Vessel Disease.Frontiers in cardiovascular medicine · 2021Review
- Anti-Aggregatory Potential of Selected Vegetables-Promising Dietary Components for the Prevention and Treatment of Cardiovascular Disease.Advances in nutrition (Bethesda, Md.) · 2019Review
- Antiplatelet protocol: Effects of ingesting a tomato pomace extract on human platelet aggregation.MethodsX · 2019Article
- Standardised tomato extract as an alternative to acetylsalicylic acid in patients with primary hypertension and high cardiovascular risk - a randomised, controlled trial.Archives of medical science : AMS · 2018Article
- Characterisation of a Hydroxycinnamic Acid Esterase From theFrontiers in microbiology · 2018Article
- Antiplatelet treatment in the primary prophylaxis of cardiovascular disease in patients with arterial hypertension.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRegular consumption of fruits and vegetables (e.g., tomatoes) has been shown to be beneficial in terms of reducing the incidence of cardiovascular diseases. The industrial processing of tomatoes into tomato-based products includes several thermal treatments. Very little is known on the effect of tomato industrial processing on antiaggregatory activity and phenolic profile.
methodsIt was assessed the effect of tomato and by-products extracts on platelet aggregation induced by ADP, collagen, TRAP-6 and arachidonic acid. These in vitro antithrombotic properties were further supported in an in vivo model of thrombosis. A set of antiplatelet compounds has been selected for HPLC analysis in the different extracts.
resultsSome natural compounds such as chlorogenic, caffeic, ferulic and p-coumaric acids were identified by HPLC in tomatoes and its products may inhibit platelet activation. Red tomatoes, tomato products (sauce, ketchup and juice) and by-products extracts inhibited platelet aggregation induced adenosine 5'-diphosphate, collagen, thrombin receptor activator peptide-6 and arachidonic acid, but to a different extent. Also, pomace extract presents antithrombotic activity.
conclusionsProcessed tomatoes may have a higher content of health-benefiting compounds than fresh ones. Pomace even presents the best antiplatelet activity. Finally, tomato products may be used as a functional ingredient adding antiplatelet activities to processed foods.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.