ReviewThrombosis and haemostasis2013
Protein degradation systems in platelets.
Review in Thrombosis and haemostasis, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Proteome and functional decline as platelets age in the circulation.Journal of thrombosis and haemostasis : JTH · 2021Article
- The Role of the Proteasome in Platelet Function.International journal of molecular sciences · 2021Review
- Extracellular Matrix-Specific Platelet Activation Leads to a Differential Translational Response and Protein De Novo Synthesis in Human Platelets.International journal of molecular sciences · 2020Article
- Platelet Proteasome Activity and Metabolism Is Upregulated during Bacterial Sepsis.International journal of molecular sciences · 2019Article
- Article
- Calpain-1 regulates platelet function in a humanized mouse model of sickle cell disease.Thrombosis research · 2017Article
- Deubiquitinases Modulate Platelet Proteome Ubiquitination, Aggregation, and Thrombosis.Arteriosclerosis, thrombosis, and vascular biology · 2015Article
- Autophagy is induced upon platelet activation and is essential for hemostasis and thrombosis.Blood · 2015Article
- Proteasome function is required for platelet production.The Journal of clinical investigation · 2014Article
- Expansion of the neonatal platelet mass is achieved via an extension of platelet lifespan.Blood · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Protein synthesis and degradation are essential processes that allow cells to survive and adapt to their surrounding milieu. In nucleated cells, the degradation and/or cleavage of proteins is required to eliminate aberrant proteins. Cells also degrade proteins as a mechanism for cell signalling and complex cellular functions. Although the last decade has convincingly shown that platelets synthesise proteins, the roles of protein degradation in these anucleate cytoplasts are less clear. Here we review what is known about protein degradation in platelets placing particular emphasis on the proteasome and the cysteine protease calpain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.