ReviewInternational journal of environmental research and public health2013
Neural tube defects, folic acid and methylation.
Review in International journal of environmental research and public health, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
113 citing papers in PubMed, 7 syntheses or guidelines pooled it, 272 citations in OpenAlex.
- Pooled it
- Birth prevalence and determinants of neural tube defects among newborns in Ethiopia: A systematic review and meta-analysis.PloS one · 2025Pooled it
- A Systematic Review of Methods and Practice for Integrating Maternal, Fetal, and Child Health Outcomes, and Family Spillover Effects into Cost-Utility Analyses.PharmacoEconomics · 2024Pooled it
- Vitamin D Supplementation and Vitamin D Status during Pregnancy and the Risk of Congenital Anomalies-A Systematic Review and Meta-Analysis.Nutrients · 2023Pooled it
- Pooled it
- Pooled it
- Magnitude and determinants of neural tube defect in Africa: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2021Pooled it
- Periconception Maternal Vitamin D Status on Nausea and Vomiting Symptoms in Early Pregnancy Among Women with a History of Pregnancy Loss.Nutrients · 2026Trial
- Folate deficiency disrupts key metabolic transitions within the developing neural ectoderm.bioRxiv : the preprint server for biology · 2026Article
- Choline and Its Companions: Inter-Related Roles of Choline and B Vitamins in Fetal Development and Offspring Health.Nutrients · 2026Review
- Dietary folate education versus once-weekly iron folic acid supplementation for improving folate status in reproductive-aged women: a quasi-experimental study.BMC nutrition · 2026Article
- A Narrative Review of Bertolotti's Syndrome: Etiology, Classification, Diagnosis, and Treatment.Cureus · 2026Review
- Analyzing Co-expression Networks with Network Skeleton Extraction.Research square · 2026Article
- Population frequencies of thiopurine-related pharmacogenes in healthy individuals from Kosovo.Human genome variation · 2026Article
- Deciphering epigenetic regulation in cardiac developmental toxicity: Mechanisms and implications (Review).Molecular medicine reports · 2026Review
- Clinicopathological profile, management and outcome of patients with congenital encephalocele: a Nigerian tertiary centre experience.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- Folic acid supplementation and neural tube defects: a cross-sectional study of knowledge and practice among pregnant mothers in Lira, Northern Uganda.BMC pregnancy and childbirth · 2026Article
- Neural Tube Defects in Resource-Limited Settings: A Lebanese Case Series Highlighting Prevention Gaps and Challenges in Prenatal Diagnosis.Case reports in obstetrics and gynecology · 2026Article
- The burden of neural tube defects in Southern Ethiopia: trends, hotspots, and public health implications.PeerJ · 2026Article
- Folate biofortification strategy by elicitation in kale baby leaves.Frontiers in plant science · 2026Article
53 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neural tube defects (NTDs) are common complex congenital malformations resulting from failure of the neural tube closure during embryogenesis. It is established that folic acid supplementation decreases the prevalence of NTDs, which has led to national public health policies regarding folic acid. To date, animal studies have not provided sufficient information to establish the metabolic and/or genomic mechanism(s) underlying human folic acid responsiveness in NTDs. However, several lines of evidence suggest that not only folates but also choline, B12 and methylation metabolisms are involved in NTDs. Decreased B12 vitamin and increased total choline or homocysteine in maternal blood have been shown to be associated with increased NTDs risk. Several polymorphisms of genes involved in these pathways have also been implicated in risk of development of NTDs. This raises the question whether supplementation with B12 vitamin, betaine or other methylation donors in addition to folic acid periconceptional supplementation will further reduce NTD risk. The objective of this article is to review the role of methylation metabolism in the onset of neural tube defects.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.