ArticleBiophysical journal2013
Model of a raft in both leaves of an asymmetric lipid bilayer.
Article in Biophysical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 60 citations in OpenAlex.
- Quantifying interleaflet coupling of phase behavior and observing anti-registered phases in asymmetric lipid bilayers.Biophysical journal · 2026Article
- Quantifying interleaflet coupling of phase behavior and observing anti-registered phases in asymmetric lipid bilayers.bioRxiv : the preprint server for biology · 2026Article
- Fluid-gel coexistence in lipid membranes under differential stress.Biophysical journal · 2022Article
- A Comprehensive Review: Sphingolipid Metabolism and Implications of Disruption in Sphingolipid Homeostasis.International journal of molecular sciences · 2021Review
- A combined molecular/continuum-modeling approach to predict the small-angle neutron scattering of curved membranes.Chemistry and physics of lipids · 2020Article
- Regimes of Complex Lipid Bilayer Phases Induced by Cholesterol Concentration in MD Simulation.Biophysical journal · 2018Article
- A Rationale for Mesoscopic Domain Formation in Biomembranes.Biomolecules · 2018Article
- Tuning Length Scales of Small Domains in Cell-Derived Membranes and Synthetic Model Membranes.Biophysical journal · 2018Article
- Intrinsic Curvature-Mediated Transbilayer Coupling in Asymmetric Lipid Vesicles.Biophysical journal · 2018Article
- Immature HIV-1 lattice assembly dynamics are regulated by scaffolding from nucleic acid and the plasma membrane.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Neutral sphingomyelinases control extracellular vesicles budding from the plasma membrane.Journal of extracellular vesicles · 2017Article
- The Continuing Mystery of Lipid Rafts.Journal of molecular biology · 2016Review
- Domain Stability in Biomimetic Membranes Driven by Lipid Polyunsaturation.The journal of physical chemistry. B · 2016Article
- Exploring in vivo cholesterol-mediated interactions between activated EGF receptors in plasma membrane with single-molecule optical tracking.BMC biophysics · 2016Article
- Transbilayer Colocalization of Lipid Domains Explained via Measurement of Strong Coupling Parameters.Biophysical journal · 2015Article
- Review
- Registered and antiregistered phase separation of mixed amphiphilic bilayers.Biophysical journal · 2015Article
- Raft formation in lipid bilayers coupled to curvature.Biophysical journal · 2014Article
- Mixed lipid bilayers with locally varying spontaneous curvature and bending.The European physical journal. E, Soft matter · 2014Article
- A theoretical study of biological membrane response to temperature gradients at the single-cell level.Journal of the Royal Society, Interface · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present a theory of inhomogeneities in the plasma membrane, or rafts, that can exist in both leaves of the plasma membrane. We note that although neither of the major phospholipid components of the outer leaf, sphingomyelin (SM) nor phosphatidylcholine (PC), evinces a tendency to form phases characterized by nonzero curvature, one of the major components of the inner leaf, phosphatidylethanolamine (PE), displays a strong tendency to do so whereas the other, phosphatidylserine (PS), does not. Therefore, we posit that the concentration difference of PS and PE couples to height fluctuations of the plasma membrane bilayer. This brings about a microemulsion in the inner leaf. Coupling of the concentration difference between PS and PE in the inner leaf and SM and PC in the outer leaf propagates the microemulsion to that leaf as well. The characteristic size of the inhomogeneities is equal to the square-root of the ratio of the bending modulus of the bilayer to its surface tension, a size which is ~100 nm for the plasma membrane. If the coupling between leaves were to be provided by the interchange of cholesterol, then our model raft would consist of SM and cholesterol in the outer leaf and PS and cholesterol in the inner leaf floating in a sea of PC and PE in both leaves.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.