ArticleBiophysical journal2013
Contractile fibers and catch-bond clusters: a biological force sensor?
Article in Biophysical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Multiscale modelling shows how cell-ECM interactions impact ECM fibre alignment and cell detachment.PLoS computational biology · 2025Article
- Emergence of multiple collective motility modes in a physical model of cell chains.NPJ systems biology and applications · 2025Article
- Emergence of slip-ideal-slip behavior in tip-links serve as force filters of sound in hearing.Nature communications · 2024Article
- How cells align to structured collagen fibrils: a hybrid cellular Potts and molecular dynamics model with dynamic mechanosensitive focal adhesions.Frontiers in cell and developmental biology · 2024Article
- Force-dependent focal adhesion assembly and disassembly: A computational study.PLoS computational biology · 2023Article
- Review
- Feedback between mechanosensitive signaling and active forces governs endothelial junction integrity.Nature communications · 2022Article
- Pulling, failing, and adaptive mechanotransduction of macrophage filopodia.Biophysical journal · 2022Article
- Convergent extension requires adhesion-dependent biomechanical integration of cell crawling and junction contraction.Cell reports · 2022Article
- Cell-extracellular matrix dynamics.Physical biology · 2022Review
- A mesoscale mechanical model of cellular interactions.Biophysical journal · 2021Article
- Stick-slip model for actin-driven cell protrusions, cell polarization, and crawling.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Cell Shape and Durotaxis Explained from Cell-Extracellular Matrix Forces and Focal Adhesion Dynamics.iScience · 2020Article
- The bioenergetics of integrin-based adhesion, from single molecule dynamics to stability of macromolecular complexes.Computational and structural biotechnology journal · 2020Review
- Dynamics of Mechanosensitive Nascent Adhesion Formation.Biophysical journal · 2019Article
- A cytoskeletal clutch mediates cellular force transmission in a soft, three-dimensional extracellular matrix.Molecular biology of the cell · 2017Article
- Mechanosensitive Adhesion Explains Stepping Motility in Amoeboid Cells.Biophysical journal · 2017Article
- Focal Adhesion Kinase: The Reversible Molecular Mechanosensor.Biophysical journal · 2017Article
- Role of catch bonds in actomyosin mechanics and cell mechanosensitivity.Physical review. E · 2016Article
- Systems mechanobiology: tension-inhibited protein turnover is sufficient to physically control gene circuits.Biophysical journal · 2014Article
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2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Catch bonds are cellular receptor-ligand pairs whose lifetime, counterintuitively, increases with increasing load. Although their existence was initially pure theoretical speculation, recent years have seen several experimental demonstrations of catch-bond behavior in biologically relevant and functional protein-protein bonds. Particularly notable among these established catch-bond formers is the integrin α5β1, the primary receptor for fibronectin and, as such, a crucial determinant for the characteristics of the mechanical coupling between cell and matrix. In this work, we explore the implications of single catch-bond characteristics for the behavior of a load-sharing cluster of such bonds: These clusters are shown to possess a regime of strengthening with increasing applied force, similar to the manner in which focal adhesions become selectively reinforced. Our results may shed new light on the fundamental processes that allow cells to sense and respond to the mechanical properties of their environment and in particular show how single focal adhesions may act, autonomously, as local rigidity sensors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.