Evidence map›Paper›PMID 24047971›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2013

Antiretroviral treatment interruptions induced by the Kenyan postelection crisis are associated with virological failure.

Marita Mann, Lameck Diero, Emmanuel Kemboi, Fidelis Mambo, Mary Rono, Wilfred Injera, Allison Delong, Leeann Schreier, Kara W Kaloustian, John Sidle and 2 more

Erratum issuedAbstract read
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  18. Impact and Cost-Effectiveness of Hypothetical Strategies to Enhance Retention in Care within HIV Treatment Programs in East Africa.Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research · 2015
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4 · The record

Corrections and comments

  • Erratum issued
    Kaloustian, Kara W [corrected to Wools-Kaloustian, Kara]
5 · Who and what money

Authors and funding

12 authors.

Marita Mann *Department of Public Health, Brown University, Providence, RI.
Lameck Diero *Department of Medicine, School of Medicine, College of Health Sciences, Moi University, Eldoret, Kenya.
Emmanuel KemboiDepartment of Medicine, School of Medicine, College of Health Sciences, Moi University, Eldoret, Kenya.
Fidelis MamboDepartment of Medicine, School of Medicine, College of Health Sciences, Moi University, Eldoret, Kenya.
Mary RonoDepartment of Medicine, School of Medicine, College of Health Sciences, Moi University, Eldoret, Kenya.
Wilfred InjeraDepartment of Medicine, School of Medicine, College of Health Sciences, Moi University, Eldoret, Kenya.
Allison DelongCenter for Statistical Sciences, Brown University, Providence, RI.
Leeann SchreierDepartment of Medicine, Division of Infectious Diseases, Warren Alpert Medical School, Brown University, Providence, RI.
Kara W KaloustianDepartment of Medicine, Division of Infectious Diseases, Indiana University, Indianapolis, IN.
John SidleDepartment of Medicine, Division of General Internal Medicine, Indiana University, Indianapolis, IN.
Nathan BuzibaDepartment of Medicine, School of Medicine, College of Health Sciences, Moi University, Eldoret, Kenya.
Rami KantorDepartment of Medicine, Division of Infectious Diseases, Warren Alpert Medical School, Brown University, Providence, RI.

Funding

East Africa International Epidemiology Database to evaluate AIDS (IeDEA) Regional ConsortiumU01AI069911 · NIAID · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI AGGREY SEMWENDERO SEMEERE, Kara Kay Wools-Kaloustian · 2006 to 2026
$57.7M
Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI CURT G BECKWITH · 1998 to 2026
$51.7M
HIV-1 Drug Resistance in Different SubtypesR01AI066922 · NIAID · STANFORD UNIVERSITY · PI KANTOR, RAMI, KATZENSTEIN, DAVID ALLENBERG · 2008 to 2012
$3.6M
Interdisciplinary Framework in Global Health at Brown UniversityR25TW008102 · FIC · BROWN UNIVERSITY · PI CU-UVIN, SUSAN · 2008 to 2010
$410k
FIC NIH HHS R25 TW008102FIC NIH HHS R25-TW008102NIAID NIH HHS 5U01AI06991NIAID NIH HHS P30 AI042853NIAID NIH HHS P30AI042853NIAID NIH HHS R01 AI066922NIAID NIH HHS R01-AI66922NIAID NIH HHS U01 AI069911
6 · The paper itself

Abstract

backgroundAntiretroviral treatment interruptions (TIs) cause suboptimal clinical outcomes. Data on TIs during social disruption are limited.

methodsWe determined effects of unplanned TIs after the 2007-2008 Kenyan postelection violence on virological failure, comparing viral load (VL) outcomes in HIV-infected adults with and without conflict-induced TI.

resultsTwo hundred and one patients were enrolled, median 2.2 years after conflict and 4.3 years on treatment. Eighty-eight patients experienced conflict-related TIs and 113 received continuous treatment. After adjusting for preconflict CD4, patients with TIs were more likely to have detectable VL, VL >5,000 and VL >10,000.

conclusionsUnplanned conflict-related TIs are associated with increased likelihood of virological failure.

Indexed as

Drug Resistance, ViralPoliticsAdultAnti-HIV AgentsCD4 Lymphocyte CountDrug Administration ScheduleDrug Therapy, CombinationFemaleHIV-1HIV InfectionsHumansKenyaMaleMiddle AgedTreatment FailureViolenceAnti-HIV Agents

Identifiers

PMID24047971
PMCPMC3920989

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.