Evidence map›Paper›PMID 24047966›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2013

Single-nucleotide polymorphisms in TrkB and risk for depression: findings from the women's interagency HIV study.

Valeriya Avdoshina, Italo Mocchetti, Chenglong Liu, Mary A Young, Kathryn Anastos, Mardge Cohen, Howard Crystal, Celeste L Pearce, Elizabeth T Golub, Rochelle E Tractenberg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Genetic Variations in EIF2AK3 are Associated with Neurocognitive Impairment in People Living with HIV.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

Valeriya AvdoshinaDepartments of *Neuroscience and †Medicine, Georgetown University Medical Center, Washington, DC; ‡Departments of Medicine and Epidemiology & Population Health, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY; §Departments of Medicine, Stroger Hospital and Rush University, Chicago, IL; ‖Departments of Neurology and Pathology, SUNY Downstate Medical Center, Brooklyn, NY; ¶Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA; #Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Departments of **Neurology; ††Biostatistics, Bioinformatics, and Biomathematics; ‡‡Psychiatry, Georgetown University Medical Center, Washington, DC; and §§Collaborative for Research on Outcomes and Metrics, Department of Neurology, Georgetown University Medical Center, Washington, DC.
Italo Mocchetti
Chenglong Liu
Mary A Young
Kathryn Anastos
Mardge Cohen
Howard Crystal
Celeste L Pearce
Elizabeth T Golub
Rochelle E Tractenberg
Albert Einstein College of Medicine · USGeorgetown University · USUniversity of Southern California · USJohns Hopkins University · USRush University · USSociety for Neuroscience · USSUNY Downstate Health Sciences University · US

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
Women's Interagency HIV Study (WIHS-V)U01AI035004 · NIAID · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI ANASTOS, KATHRYN M., SHARMA, ANJALI · 1993 to 2018
$65.7M
WOMEN'S INTERAGENCY HIV STUDY ORGANIZATION, MANAGEMENT AND COMMUNICATIONSU01AI034989 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, GREENBLATT, RUTH MARTHA · 1993 to 2018
$65.6M
Women's Interagency HIV Study (WIHS) IIIU01AI031834 · NIAID · SUNY DOWNSTATE MEDICAL CENTER · PI GUSTAFSON, DEBORAH R., MINKOFF, HOWARD · 1998 to 2018
$53.5M
WOMEN'S INTERAGENCY HIV STUDY (WIHS) ORGANIZATION AND MANAGEMENTU01AI034994 · NIAID · GEORGETOWN UNIVERSITY · PI KASSAYE, SEBLE G · 1993 to 2018
$52.0M
Women's Interagency HIV Study (WIHS) IV, Chicago ConsortiumU01AI034993 · NIAID · HEKTOEN INSTITUTE FOR MEDICAL RESEARCH · PI COHEN, MARDGE H, FRENCH, AUDREY · 1994 to 2018
$51.0M
WOMENS INTERAGENCY HIV STUDY (WIHS)U01HD032632 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MILAM, JOEL E · 1994 to 2012
$42.0M
WIHS DATA MANAGEMENT AND ANALYSIS CENTER(WDMAC)U01AI042590 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GANGE, STEPHEN J, GOLUB, ELIZABETH T · 1998 to 2018
$38.4M
Tissue Culture and Virology Laboratory CoreP01AI082971 · NIAID · RUSH UNIVERSITY MEDICAL CENTER · PI LANDAY, ALAN L · 2009 to 2013
$11.2M
Role of proBNDF and p75NTR in HIV-mediated Axonal/Dendritic DegenerationR01NS079172 · NINDS · GEORGETOWN UNIVERSITY · PI Italo Mocchetti · 2012 to 2026
$7.0M
Translational Research in Neuro-AIDS and Mental HealthR25MH080661 · NIMH · JOHNS HOPKINS UNIVERSITY · PI MCARTHUR, JUSTIN CHARLES. · 2007 to 2019
$2.9M
HIV drug abusers, polymorphisms and brain plasticityR01DA026174 · NIDA · GEORGETOWN UNIVERSITY · PI MOCCHETTI, ITALO · 2008 to 2012
$1.8M
NCRR NIH HHS UL1 RR024131NIAID NIH HHS P01 AI082971NIAID NIH HHS U01 AI031834NIAID NIH HHS U01 AI034989NIAID NIH HHS U01 AI034993NIAID NIH HHS U01 AI034994NIAID NIH HHS U01 AI035004NIAID NIH HHS U01 AI042590NIAID NIH HHS U01-AI-31834NIAID NIH HHS U01-AI-34989NIAID NIH HHS U01-AI-34993NIAID NIH HHS U01-AI-34994NIAID NIH HHS U01-AI-35004NIAID NIH HHS U01-AI-42590NICHD NIH HHS U01 HD032632NICHD NIH HHS U01-HD-32632NIDA NIH HHS 1R01-DA026174NIDA NIH HHS R01 DA026174NIMH NIH HHS R25 MH080661NINDS NIH HHS R01 NS079172
6 · The paper itself

Abstract

Individuals infected with HIV type 1 are more likely than noninfected individuals to develop depression. HIV lowers brain-derived neurotrophic factor (BDNF), a neurotrophic factor whose receptors play a crucial role in the pathophysiology of depression. Therefore, we examined whether a single-nucleotide polymorphism in the BDNF gene (rs56164415) and related receptors TrkB (rs1212171) and p75 (rs2072446) were associated with depression in HIV-infected individuals. A total of 1365 HIV-positive and 371 HIV-negative female subjects were included. The distribution of alleles was analyzed independently in African Americans (non-Hispanic) and Caucasians (non-Hispanic). We have found that the absence of depressive symptoms in HIV-positive subjects is associated with a genetic variation of the TrkB but not with BDNF or p75 genes. This mutation explains 0.8% and 4.4% of the variability for the absence of depression in African Americans and Caucasians, respectively.

Indexed as

Genetic Association StudiesAllelesBlack or African AmericanBrain-Derived Neurotrophic FactorDepressive DisorderFemaleGenotypeHIV InfectionsHumansMiddle AgedNerve Tissue ProteinsPolymorphism, Single NucleotideReceptors, Nerve Growth FactorReceptor, trkBRisk FactorsWhite PeopleBDNF protein, humanBrain-Derived Neurotrophic FactorNerve Tissue ProteinsNGFR protein, humanReceptors, Nerve Growth FactorReceptor, trkB

Identifiers

PMID24047966
PMCPMC3780967
OpenAlexW2076440739

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.