ArticleJournal of neurophysiology2013
Functional significance of cortical NMDA receptors in somatosensory information processing.
Article in Journal of neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- GluN2C/D-containing NMDA receptors enhance temporal summation and increase sound-evoked and spontaneous firing in the inferior colliculus.The Journal of physiology · 2025Article
- GluN2C/D-containing NMDA receptors enhance temporal summation and increase sound-evoked and spontaneous firing in the inferior colliculus.bioRxiv : the preprint server for biology · 2024Article
- Amyloid Deposition and Dendritic Complexity of Corticocortical Projection Cells in Five Familial Alzheimer's Disease Mouse.Neuroscience · 2023Article
- NMDA receptors in visual cortex are necessary for normal visuomotor integration and skill learning.eLife · 2022Article
- Genetically identified neurons in avian auditory pallium mirror core principles of their mammalian counterparts.Current biology : CB · 2021Article
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- Insulin receptor sensitization restores neocortical excitation/inhibition balance in a mouse model of autism.Molecular autism · 2018Article
- Behavioral Consequences of a Bifacial Map in the Mouse Somatosensory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- In Vivo Mesoscopic Voltage-Sensitive Dye Imaging of Brain Activation.Scientific reports · 2016Article
- Enhancement of postsynaptic GABAA and extrasynaptic NMDA receptor-mediated responses in the barrel cortex of Mecp2-null mice.Journal of neurophysiology · 2016Article
- Study of the cortical representation of whisker frequency selectivity using voltage-sensitive dye optical imaging.Intravital · 2016Article
- Sensory Activity-Dependent and Sensory Activity-Independent Properties of the Developing Rodent Trigeminal Principal Nucleus.Developmental neuroscience · 2016Review
- In Vivo Voltage-Sensitive Dye Imaging of Subcortical Brain Function.Scientific reports · 2015Article
- Thalamic NMDA receptor function is necessary for patterning of the thalamocortical somatosensory map and for sensorimotor behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Two types of auditory glutamatergic synapses and their implications for repairing damaged central auditory pathways.Neural regeneration research · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
N-methyl-d-aspartate receptor (NMDAR)-mediated activity is required for whisker-related neural patterning in the rodent brain. Deletion of the essential NMDAR subunit NR1 gene in excitatory cortical neurons prevents whisker-specific barrel formation and impairs thalamocortical afferent patterning. We used electrophysiological and voltage-sensitive dye imaging methods to assess synaptic and sensory evoked cortical activity and immunohistochemistry to examine immediate early gene expression following whisker stimulation in cortex-specific NR1 knockout (CxNR1KO) mice. In mutant mice, layer IV neurons lacked NMDAR-mediated excitatory postsynaptic currents, and temporal summation of excitatory postsynaptic potentials (EPSPs) was impaired. Barrel neurons showed both phasic and tonic responses to whisker deflection. The averaged tonic response in CxNR1KO mice was significantly less than that in control mice due to impaired EPSP temporal summation. Electrophysiological estimation of the number of thalamic neurons innervating single barrel neurons indicated a significant increase in CxNR1KO mice. Similarly, voltage-sensitive dye optical signals in response to whisker stimulation were widespread. Immediate early gene expression following whisker stimulation also showed a diffuse expression pattern in the CxNR1KO cortex compared with whisker-specific expression patterns in controls. Thus, when NMDAR function is impaired, spatial discrimination of whisker inputs is severely compromised, and sensory stimulation evokes diffuse, topographically misaligned activity in the barrel cortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.