Evidence map›Paper›PMID 24047885›Full record

ArticleInternational journal of STD & AIDS2014

Individual and partner risk factors associated with abnormal cervical cytology among women in HIV-discordant relationships.

Jason Soh, Anne F Rositch, Laura Koutsky, Brandon L Guthrie, Robert Y Choi, Rose K Bosire, Ann Gatuguta, Jennifer S Smith, James Kiarie, Barbara Lohman-Payne and 1 more

Abstract read
In one paragraph

Article in International journal of STD & AIDS, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 2 countries.

Jason SohSchool of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Anne F Rositch
Laura Koutsky
Brandon L Guthrie
Robert Y Choi
Rose K Bosire
Ann Gatuguta
Jennifer S Smith
James Kiarie
Barbara Lohman-Payne
Carey Farquhar
University of Washington · USJohns Hopkins University · USKenya Medical Research Institute · KEKenyatta University · KEUniversity of Nairobi · KEUniversity of North Carolina at Chapel Hill · USVirginia Commonwealth University · US

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI EDWIN ROBERTO ORELLANA · 1988 to 2026
$104.9M
Fogarty International Clinical Research Scholars Support Center @ Vanderbilt-AAMCR24TW007988 · FIC · VANDERBILT UNIVERSITY · PI VERMUND, STEN H. · 2007 to 2011
$27.6M
VENEREAL DISEASET32AI007140 · NIAID · UNIVERSITY OF WASHINGTON · PI Julia Cook Dombrowski · 1985 to 2026
$19.4M
INTERNATIONAL TRAINING GRANT IN EPIDEMIOLOGYD43TW000007 · FIC · UNIVERSITY OF WASHINGTON · PI FARQUHAR, CAREY · 1988 to 2012
$16.3M
Northern/Pacific Universities Global Health Research Training ConsortiumR25TW009345 · FIC · UNIVERSITY OF WASHINGTON · PI KOLARS, JOSEPH C., NERURKAR, VIVEK RAMCHANDRA · 2012 to 2016
$5.9M
Protective cellular immune responses in HIV-1 discordant couplesR01AI068431 · NIAID · UNIVERSITY OF WASHINGTON · PI FARQUHAR, CAREY · 2006 to 2010
$3.1M
HIV-1 and Protective Immunity against Common Childhood PathogensK24AI087399 · NIAID · UNIVERSITY OF WASHINGTON · PI FARQUHAR, CAREY · 2010 to 2014
$647k
Overcoming Barriers to HIV/AIDS Care and ART InitiationK01AI098527 · NIAID · UNIVERSITY OF WASHINGTON · PI GUTHRIE, BRANDON LODGE · 2012 to 2016
$647k
Protective Immune Responses in HIV-1 Exposed InfantsK23HD041879 · NICHD · UNIVERSITY OF WASHINGTON · PI FARQUHAR, CAREY · 2002 to 2006
$628k
CTL responses in HIV-1 infected infantsK01TW006080 · FIC · UNIVERSITY OF WASHINGTON · PI PAYNE, BARBARA LOUISE · 2002 to 2005
$495k
The role of HIV-1 neutralizing mucosal IgA and lgG and genital shedding of HIV-1K01TW008406 · FIC · UNIVERSITY OF WASHINGTON · PI CHOI, ROBERT · 2010 to 2012
$366k
FIC NIH HHS D43 TW000007FIC NIH HHS D43 TW00007FIC NIH HHS K01 TW006080FIC NIH HHS K01 TW008406FIC NIH HHS K01 TW06080FIC NIH HHS R24 TW007988FIC NIH HHS R25 TW009345NIAID NIH HHS K01 AI098527NIAID NIH HHS K24 AI087399NIAID NIH HHS L30 AI097101NIAID NIH HHS P30 AI027757NIAID NIH HHS R01 AI068431NIAID NIH HHS T32 AI007140NIAID NIH HHS T32 AI07140NICHD NIH HHS K23 HD041879NICHD NIH HHS K23 HD41879
6 · The paper itself

Abstract

Individual and sexual partner characteristics may increase the risk of abnormal cervical cytology among women in human immunodeficiency virus (HIV)-discordant relationships. Papanicolaou smears were obtained in a prospective cohort of Kenyan HIV-discordant couples. Of 441 women, 283 (64%) were HIV-infected and 158 (36%) were HIV-uninfected with HIV-infected partners. Overall, 79 (18%) had low-grade and 25 (6%) high-grade cervical abnormalities. Male herpes simplex virus type 2 (HSV-2) seropositivity and lower couple socioeconomic status were associated with cervical abnormalities (p < 0.05). HIV-uninfected women with HIV-infected male sex partners (CD4 > 350 cells/µL) had the lowest prevalence of high-grade cervical lesions. HIV-infected women (CD4 > 350 cells/µL) and HIV-uninfected women with HIV-infected partners (CD4 ≤ 350 cells/µL) were at similar intermediate risk (p > 0.05), and HIV-infected women (CD4 ≤ 350 cells/µL) had significantly higher risk of high-grade cervical abnormalities (p = 0.05). Women in HIV-discordant relationships have high rates of cervical lesions and this may be influenced by couple-level factors, including HIV status and CD4 count of the infected partner.

Indexed as

Sexual PartnersAdultCD4 Lymphocyte CountFemaleHIV-1HIV SeropositivityHumansKenyaMaleMiddle AgedPapillomaviridaePapillomavirus InfectionsPrevalenceProspective StudiesRisk FactorsSocioeconomic FactorsAfricaAIDScervical cancercervical intraepithelial neoplasiacytologydiscordant couplesHIVHPVhuman papillomavirussexually transmitted infection

Identifiers

PMID24047885
PMCPMC3968186
OpenAlexW1997036014

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.