ArticleJournal of the Royal Society, Interface2013
An energetic model for macromolecules unfolding in stretching experiments.
Article in Journal of the Royal Society, Interface, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 45 citations in OpenAlex.
- Capsules Rheology in Carreau-Yasuda Fluids.Nanomaterials (Basel, Switzerland) · 2020Article
- Stick-slip kinetics in a bistable bar immersed in a heat bath.International journal of solids and structures · 2019Article
- Unveiling the influence of device stiffness in single macromolecule unfolding.Scientific reports · 2019Article
- Multi-scale modelling of rubber-like materials and soft tissues:Proceedings. Mathematical, physical, and engineering sciences · 2016Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We propose a simple approach, based on the minimization of the total (entropic plus unfolding) energy of a two-state system, to describe the unfolding of multi-domain macromolecules (proteins, silks, polysaccharides, nanopolymers). The model is fully analytical and enlightens the role of the different energetic components regulating the unfolding evolution. As an explicit example, we compare the analytical results with a titin atomic force microscopy stretch-induced unfolding experiment showing the ability of the model to quantitatively reproduce the experimental behaviour. In the thermodynamic limit, the sawtooth force-elongation unfolding curve degenerates to a constant force unfolding plateau.
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