ReviewExperientia1990
The pineal and melatonin: regulators of circadian function in lower vertebrates.
Review in Experientia, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Melatonin promotes sleep by suppressing responses to visual stimuli via MT1 receptors.Current biology : CB · 2026Article
- Phytomelatonin in Ornamental Horticulture: A Comprehensive Review of Growth Promotion, Stress Tolerance, and Post-Harvest Quality.International journal of molecular sciences · 2026Review
- A mathematical model for the role of dopamine-D2 self-regulation in the production of ultradian rhythms.PLoS computational biology · 2024Article
- Pituitary Hormones mRNA Abundance in the Mediterranean Sea BassFrontiers in physiology · 2021Article
- Exposure to Artificial Light at Night and the Consequences for Flora, Fauna, and Ecosystems.Frontiers in neuroscience · 2020Review
- Peripheral Circadian Oscillators.The Yale journal of biology and medicine · 2019Review
- Melatonin and Its Effects on Plant Systems.Molecules (Basel, Switzerland) · 2018Review
- Seasonal Reproduction in Vertebrates: Melatonin Synthesis, Binding, and Functionality Using Tinbergen's Four Questions.Molecules (Basel, Switzerland) · 2018Review
- Influence of light intensity and spectral composition of artificial light at night on melatonin rhythm and mRNA expression of gonadotropins in roach Rutilus rutilus.Fish physiology and biochemistry · 2018Article
- Genetically Blocking the Zebrafish Pineal Clock Affects Circadian Behavior.PLoS genetics · 2016Article
- The melanocyte photosensory system in the human skin.SpringerPlus · 2013Article
- Circadian expression of Bmal1 and serotonin-N-acetyltransferase mRNAs in chicken retina cells and pinealocytes in vivo and in vitro.Journal of molecular neuroscience : MN · 2006Article
- Circadian rhythms in the suprachiasmatic nucleus are temperature-compensated and phase-shifted by heat pulses in vitro.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Multioscillatory circadian organization in a vertebrate, iguana iguana.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Partial characterization of serotonin N - acetyltransferases from northern pike (Esox lucius, L.) pineal organ and retina: effects of temperature.Pflugers Archiv : European journal of physiology · 1996Article
- Rhythmic melatonin secretion in different teleost species: an in vitro study.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 1996Article
- Spectral sensitivity and mechanism of interaction between inhibitory and excitatory responses of photosensory pineal neurons.Pflugers Archiv : European journal of physiology · 1994Article
- The melatonin rhythm: both a clock and a calendar.Experientia · 1993Review
- Melatonin modulates the neural activity in photosensory pineal organ of the trout: evidence for endocrine-neuronal interactions.Journal of comparative physiology. A, Sensory, neural, and behavioral physiology · 1990Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pineal has been identified as a major circadian pacemaker within the circadian system of a number of lower vertebrates although other pacemaking sites have been implicated as well. The rhythmic synthesis and secretion of the pineal hormone, melatonin, is suggested as the mechanism by which the pineal controls circadian oscillators located elsewhere. Both light and temperature cycles can entrain the pineal melatonin rhythm. The pineal, therefore, acts as a photo and thermoendocrine transducer which functions to synchronize internal cycle with cycles in the environment. A model is presented which portrays the pineal as a major component of a 'multioscillator' circadian system and which suggests how these multiple circadian clocks are coupled to each other and to cycles of light and temperature in the external world.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.