ArticleThe Journal of nutrition2013
Expression of the placental transcriptome in maternal nutrient reduction in baboons is dependent on fetal sex.
Article in The Journal of nutrition, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 41 citations in OpenAlex.
- The Baboon as a Model to Study Human Health and Complex Disease.American journal of primatology · 2026Review
- Sexual Dimorphism in Placental mTORC1 Signaling, Amino Acid Transport, and Mitochondrial Respiration at Term.Antioxidants (Basel, Switzerland) · 2026Article
- Maternal high-fat high-energy diet impairs surfactant maturation in the non-human primate fetal lung.International journal of obesity (2005) · 2026Article
- Insights from animal models: Dissecting the independent roles of oxygen and nutrients in the fetal origins of cardiovascular disease.The Journal of physiology · 2026Review
- Moderate maternal nutrient restriction alters type II alveolar epithelial cell density in the non-human primate fetal lung.Experimental physiology · 2026Article
- Sexually dimorphic responses in androgen metabolism and signalling in the non-human primate placenta to moderate maternal undernutrition.Biology of sex differences · 2025Article
- Maternal obesity alters the placental transcriptome in a fetal sex-dependent manner.Frontiers in cell and developmental biology · 2023Article
- The Placenta's Role in Sexually Dimorphic Fetal Growth Strategies.Reproductive sciences (Thousand Oaks, Calif.) · 2022Review
- Perfluoroalkyl Substances (PFAS) and Their Effects on the Placenta, Pregnancy, and Child Development: a Potential Mechanistic Role for Placental Peroxisome Proliferator-Activated Receptors (PPARs).Current environmental health reports · 2020Review
- Sex-specific difference in placental inflammatory transcriptional biomarkers of maternal phthalate exposure: a prospective cohort study.Journal of exposure science & environmental epidemiology · 2020Article
- Strength of nonhuman primate studies of developmental programming: review of sample sizes, challenges, and steps for future work.Journal of developmental origins of health and disease · 2020Review
- Complex, coordinated and highly regulated changes in placental signaling and nutrient transport capacity in IUGR.Biochimica et biophysica acta. Molecular basis of disease · 2020Review
- Review
- Maternal dyslipidemia during early pregnancy and epigenetic ageing of the placenta.Epigenetics · 2019Article
- Analysis of serum changes in response to a high fat high cholesterol diet challenge reveals metabolic biomarkers of atherosclerosis.PloS one · 2019Article
- Maternal healthy lifestyle during early pregnancy and offspring birthweight: differences by offspring sex.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2018Article
- Effect of moderate, 30 percent global maternal nutrient reduction on fetal and postnatal baboon phenotype.Journal of medical primatology · 2017Article
- High Fat Diets Sex-Specifically Affect the Renal Transcriptome and Program Obesity, Kidney Injury, and Hypertension in the Offspring.Nutrients · 2017Article
- Developmental Origins of Chronic Kidney Disease: Should We Focus on Early Life?International journal of molecular sciences · 2017Review
- Aliskiren Administration during Early Postnatal Life Sex-Specifically Alleviates Hypertension Programmed by Maternal High Fructose Consumption.Frontiers in physiology · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Maternal undernutrition increases the risk of perinatal complications and predisposes offspring to obesity, diabetes, and cardiovascular disease later in life. Emerging evidence suggests that changes in placental function play a role in linking altered maternal nutrition in pregnancy to the subsequent development of adult disease. The susceptibility for disease in response to an adverse intrauterine environment differs distinctly between boys and girls, with girls typically having better outcomes. Here, we tested the hypothesis that regulation of the placental transcriptome by maternal nutrient reduction (NR) is dependent on fetal sex. We used a nonhuman primate model of NR in which maternal global food intake was reduced by 30% in baboons starting at gestational day (GD) 30. At GD 165 (term = GD 183), placental genome expression profiling of 6 control (n = 3 females, 3 males) and 6 nutrient restricted (n = 3 females, 3 males) fetuses was carried out followed by bioinformatic analysis. Surprisingly, there was no coordinated placental molecular response to decreased nutrient availability when analyzing the data without accounting for fetal sex. In contrast, female placentas exhibited a highly coordinated response that included upregulation of genes in networks, pathways, and functional groups related to programmed cell death and downregulation of genes in networks, pathways, and functional groups associated with cell proliferation. These changes were not apparent in the male placentas. Our data support the concept that female placentas initiate complex adaptive responses to an adverse intrauterine environment, which may contribute to increased survival and better pregnancy outcomes in girls.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.