ArticleCell cycle (Georgetown, Tex.)2013
Pom1 and cell size homeostasis in fission yeast.
Article in Cell cycle (Georgetown, Tex.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44 citing papers in PubMed, 90 citations in OpenAlex.
- The MO25 protein Pmo25 functions in contractile ring stability and Sid2 localization during cytokinesis.iScience · 2026Article
- A growing problem: The many unsolved mysteries of cell growth.Molecular biology of the cell · 2025Review
- Roles of the MO25 protein Pmo25 in contractile-ring stability and localization of the NDR kinase Sid2 during cytokinesis.bioRxiv : the preprint server for biology · 2025Article
- MaPom1, a Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase, Positively Regulates Thermal and UV-B Tolerance inInternational journal of molecular sciences · 2024Article
- A Moments-Based Analytical Approach for Cell Size Homeostasis.IEEE control systems letters · 2024Article
- The fission yeast cell size control system integrates pathways measuring cell surface area, volume, and time.Current biology : CB · 2023Article
- Implications of differential size-scaling of cell-cycle regulators on cell size homeostasis.PLoS computational biology · 2023Article
- Concentration fluctuations in growing and dividing cells: Insights into the emergence of concentration homeostasis.PLoS computational biology · 2022Article
- A quantitative and spatial analysis of cell cycle regulators during the fission yeast cycle.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- What programs the size of animal cells?Frontiers in cell and developmental biology · 2022Review
- Characterizing non-exponential growth and bimodal cell size distributions in fission yeast: An analytical approach.PLoS computational biology · 2022Article
- The Ceramide Synthase Subunit Lac1 Regulates Cell Growth and Size in Fission Yeast.International journal of molecular sciences · 2021Article
- CDK control pathways integrate cell size and ploidy information to control cell division.eLife · 2021Article
- Direct and indirect regulation of Pom1 cell size pathway by the protein phosphatase 2C Ptc1.Molecular biology of the cell · 2021Article
- Scaling gene expression for cell size control and senescence in Saccharomyces cerevisiae.Current genetics · 2021Review
- Pomegranate: 2D segmentation and 3D reconstruction for fission yeast and other radially symmetric cells.Scientific reports · 2020Article
- Cell-size regulation in budding yeast does not depend on linear accumulation of Whi5.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Differential Scaling of Gene Expression with Cell Size May Explain Size Control in Budding Yeast.Molecular cell · 2020Article
- Reassessment of the Basis of Cell Size Control Based on Analysis of Cell-to-Cell Variability.Biophysical journal · 2019Article
- Involvement of CaMKII in regulating the release of diplotene-arrested mouse oocytes by pAkt1 (Ser473).Cell cycle (Georgetown, Tex.) · 2019Article
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2 authors at 2 institutions in 3 countries.
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Abstract
Cells sense their size and use this information to coordinate cell division with cell growth to maintain a constant cell size within a given population. A model has been proposed for cell size control in the rod-shaped cells of the fission yeast, Schizosaccharomyces pombe. This involves a protein localized to the cell ends, which inhibits mitotic activators in the middle of the cell in a cell size-dependent manner. This protein, Pom1, along with another tip-localized protein, Nif1, have been implicated as direct sensors of cell size controlling the onset of mitosis. Here we have investigated cell size variability and size homeostasis at the G 2/M transition, focusing on the role of pom1 and nif1. Cells deleted for either of these 2 genes show wild-type size homeostasis both in size variability analyses and size homeostasis experiments. This indicates that these genes do not have a critical role as direct cell size sensors in the control mechanism. Cell size homeostasis also seems to be independent of Cdc2-Tyr15 phosphorylation, suggesting that the size sensing mechanism in fission yeast may act through an unidentified pathway regulating CDK activity by an unknown mechanism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.