ArticleAnnals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc2013
Heart rate variability and heart rate turbulence in HIV-infected patients receiving combination antiretroviral therapy.
Article in Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Prevalence and risk factors of cardiovascular disease among people living with HIV in the Asia-Pacific region: a systematic review.BMC public health · 2023Pooled it
- A meta-analysis of HIV and heart rate variability in the era of antiretroviral therapy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2016Pooled it
- Autonomic Neuropathy as a Predictor of Morbidity and Mortality in People Living With HIV: A Retrospective, Longitudinal Cohort Study.Neurology. Clinical practice · 2023Article
- A Systematic Review Exploring the Effect of Human Immunodeficiency Virus on Cardiac Diseases.Cureus · 2022Review
- Association between exposure to Efavirenz and substrates of dysrhythmia in HIV-infected young adults.Clinical cardiology · 2021Article
- Linear and non-linear analysis of heart rate variability in HIV-positive patients on two different antiretroviral therapy regimens.BMC infectious diseases · 2021Article
- Heart Rate Variability, HIV and the Risk of Cardiovascular Diseases in Rural South Africa.Global heart · 2020Article
- QT dispersion in HIV-infected patients receiving combined antiretroviral therapy.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2014Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies have demonstrated the presence of autonomic dysfunction in human immunodeficiency virus (HIV)-infected patients. However, the data in those receiving combination antiretroviral therapy (cART) are conflicting. The aim of this study was to assess the autonomic function using heart rate variability (HRV) and heart rate turbulence (HRT) analysis in HIV-infected patients receiving cART.
methodsEighty-one HIV-infected patients receiving cART and 42 control subjects were enrolled in the study. The HRV and HRT parameters were assessed on 24-hour digital Holter electrocardiogram recordings.
resultsBaseline characteristics were comparable between HIV-infected and control subjects, except the higher fasting glucose and triglyceride and lower high-density lipoprotein cholesterol observed in HIV-infected patients. All components of HRV were significantly reduced in HIV-infected patients. After adjustment with biochemical parameters, most of the HRV parameters were still significantly reduced in HIV-infected patients. However, HRV parameters reflecting vagal activity were no longer different between 2 groups. In addition, HRT parameters did not differ between HIV-infected and control subjects. The standard deviation of normal-to-normal intervals significantly correlated with CD4 lymphocyte counts in HIV-infected patients but did not with protease inhibitors therapy.
conclusionsWe demonstrated the overall decrease in HRV in HIV-infected patients receiving cART. The metabolic disturbance observed in HIV-infected patients possibly accounted for decreased vagal activity.
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