Trial reportAmerican journal of respiratory and critical care medicine2013
Diagnosis and subtyping of de novo and relapsed mediastinal lymphomas by endobronchial ultrasound needle aspiration.
Trial report in American journal of respiratory and critical care medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 92 citations in OpenAlex.
- Diagnostic Yield of EBUS Mediastinal Cryobiopsy Versus TBNA in Suspected Lymphoproliferative Disorders: A Prospective Multicentre Study.Respirology (Carlton, Vic.) · 2026Article
- Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration With 19-Gauge vs 21- or 22-Gauge Needle for Mediastinal Lymphadenopathy: An Updated Analysis of the SCOPE Database.CHEST pulmonary · 2026Article
- Does needle size affect the diagnostic yield of endobronchial ultrasound-guided transbronchial needle aspiration for malignant lymphoma?-a narrative review.Mediastinum (Hong Kong, China) · 2026Review
- The evolving role of interventional pulmonology with endobronchial ultrasonography in the diagnosis of lymphoma: a narrative review.Mediastinum (Hong Kong, China) · 2026Review
- Enhancing diagnostic precision: a multicentric study of endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy in lymphoproliferative disorders.ERJ open research · 2025Article
- Assessment of endobronchial ultrasound-guided bronchoscopy (EBUS) intranodal forceps biopsy added to EBUS 19-gauge transbronchial needle aspiration: A blinded pathology panel analysis.Thoracic cancer · 2023Article
- Endobronchial Ultrasound-Guided Transbronchial Forceps Biopsy: A Retrospective Bicentric Study Using the Olympus 1.5 mm Mini-Forceps.Journal of clinical medicine · 2022Article
- Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (EBUS-TBNA): Technical Updates and Pathological Yield.Diagnostics (Basel, Switzerland) · 2021Review
- Improved Diagnostic Yield and Specimen Quality With Endobronchial Ultrasound-Guided Forceps Biopsies: A Retrospective Analysis.The Annals of thoracic surgery · 2020Article
- Endobronchial ultrasound-guided intranodal forceps biopsy (EBUS-IFB)-technical review.Journal of thoracic disease · 2019Review
- A pragmatic application of endobronchial ultrasound-guided transbronchial needle aspiration: a single institution experience.BMC pulmonary medicine · 2019Article
- [Next Steps after Negative Results Obtained by EBUS-TBNA from Patients Suspected Clinically Lung Cancer with Mediastinal Lymphnode Metastasis].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2019Article
- [Lung involvement in hematologic systemic diseases].Der Internist · 2018Review
- Interstitial lung disease: the diagnostic role of bronchoscopy.Journal of thoracic disease · 2017Review
- Understanding local performance data for EBUS-TBNA: insights from an unselected case series at a high volume UK center.Journal of thoracic disease · 2017Article
- The role of bronchoscopy in the diagnosis of airway disease.Journal of thoracic disease · 2016Review
- Recent advances in diagnostic bronchoscopy.Journal of thoracic disease · 2016Review
- Ultrasound techniques in the evaluation of the mediastinum, part 2: mediastinal lymph node anatomy and diagnostic reach of ultrasound techniques, clinical work up of neoplastic and inflammatory mediastinal lymphadenopathy using ultrasound techniques and how to learn mediastinal endosonography.Journal of thoracic disease · 2015Review
- Ultrasound techniques in the evaluation of the mediastinum, part I: endoscopic ultrasound (EUS), endobronchial ultrasound (EBUS) and transcutaneous mediastinal ultrasound (TMUS), introduction into ultrasound techniques.Journal of thoracic disease · 2015Review
- Update in Lung Cancer 2014.American journal of respiratory and critical care medicine · 2015Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
rationaleThe current management of lymphoma requires accurate diagnosis and subtyping of de novo lymphoma and of relapsed or refractory lymphoma in known cases. The role of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in the clinical management of lymphomas is unclear.
objectivesTo investigate the use of EBUS-TBNA in the diagnosis of de novo and relapsed mediastinal lymphomas.
methodsA total of 2,256 consecutive patients who underwent EBUS-TBNA in a tertiary center between February 2008 and April 2013 were prospectively evaluated. The diagnostic accuracy and clinical use of EBUS-TBNA in 100 cases of de novo or suspected relapsed mediastinal lymphoma was investigated by comparing EBUS-TBNA diagnosis with the final diagnosis. MEASUREMENTS AND MAIN
resultsDe novo mediastinal lymphoma was correctly diagnosed by EBUS-TBNA in 45 (88%) of 51 and relapsed lymphoma in 15 (100%) of 15 lymphoma cases. EBUS-TBNA accurately established a diagnosis other than lymphoma in 32 (97%) of 33 patients with suspected lymphoma relapse. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of EBUS-TBNA in the diagnosis of mediastinal lymphoma were 89%, 97%, 98%, 83%, and 91%, respectively. Sensitivity of EBUS-TBNA in subtyping lymphomas into high-grade non-Hodgkin lymphoma, low-grade non-Hodgkin lymphoma, and Hodgkin lymphoma was 90%, 100%, and 79%, respectively. EBUS-TBNA diagnosis was adequate for clinical management in 84 (84%) of 100 cases.
conclusionsMultimodality evaluation of EBUS-TBNA can be successful in the diagnosis of de novo mediastinal lymphomas and is ideally suited in distinguishing lymphoma relapse from alternative pathologies; it is least sensitive in subtyping Hodgkin lymphoma.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.