Evidence map›Paper›PMID 24047060›Full record

Trial reportThe New England journal of medicine2013

Long-term mortality after screening for colorectal cancer.

Aasma Shaukat, Steven J Mongin, Mindy S Geisser, Frank A Lederle, John H Bond, Jack S Mandel, Timothy R Church

2 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in The New England journal of medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 414 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
414citing papers in PubMed, 11 pooled it
33.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02717598 nacompletednot on this mapstarted 2016, after this paper: background citation

Cold Snare Polypectomy Versus Hot Snare Polypectomy for Diminutive and Small Colorectal Polyps: a Randomized Controlled Trial

TypeinterventionalSponsorWulumuqi General Hospital of Lanzhou Military CommandRan2016 to 2017Enrolled198ConditionsColonic Polyp, Intestinal PolypArmscold snare polypectomy, hot snare polypectomy
NCT07628998 narecruitingnot on this mapstarted 2026, after this paper: background citation

Impact of SMS Notifications on the Colorectal Cancer Screening Program

TypeinterventionalSponsorCorporacion Parc TauliRan2026 to 2026Enrolled10,084ConditionsColorectal Neoplasms, Early Detection of CancerArmsText Messaging, Standard invitation and postal reminder letters
3 · Its place in the literature

Who cites it

414 citing papers in PubMed, 11 syntheses or guidelines pooled it, 834 citations in OpenAlex.

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  14. Sex-Specific Outcomes after a Negative Colonoscopy in the Finnish Randomized Health Service Study during 2004 to 2016.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
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354 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Aasma ShaukatDivision of Gastroenterology, Minneapolis Veterans Affairs Health Care System, Minneapolis, USA.
Steven J Mongin
Mindy S Geisser
Frank A Lederle
John H Bond
Jack S Mandel
Timothy R Church
Minneapolis VA Health Care System · USUniversity of Minnesota · USExponent (United States) · US

Funding

SCREENING TECHNIQUE FOR DETECTING EARLY CANCER OF BOWELN01CB053862 · CB · UNIVERSITY OF MINNESOTA TWIN CITIES · PI GILBERTSEN, VICTOR A · 1985 to 1986
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HEMOCULT SCREENING TECHNIQUES FOR BOWEL CANCERN01CB061005 · CB · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MANDEL, JACK S · 1986 to 1991
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PERIODIC SCREENING FOR OCCULT STOOL BLOODN01CB095613 · CB · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MANDEL, JACK S · 1989 to 1995
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RANDOMIZED TRIAL TO EVALUATE SCREENING FOR COLON CANCERR01CA065728 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI CHURCH, TIMOTHY ROBERT · 1995 to 1999
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NCI NIH HHS N01CB53862NCI NIH HHS N01CB61005NCI NIH HHS N01CB95613NCI NIH HHS R01CA65728
6 · The paper itself

Abstract

backgroundIn randomized trials, fecal occult-blood testing reduces mortality from colorectal cancer. However, the duration of the benefit is unknown, as are the effects specific to age and sex.

methodsIn the Minnesota Colon Cancer Control Study, 46,551 participants, 50 to 80 years of age, were randomly assigned to usual care (control) or to annual or biennial screening with fecal occult-blood testing. Screening was performed from 1976 through 1982 and from 1986 through 1992. We used the National Death Index to obtain updated information on the vital status of participants and to determine causes of death through 2008.

resultsThrough 30 years of follow-up, 33,020 participants (70.9%) died. A total of 732 deaths were attributed to colorectal cancer: 200 of the 11,072 deaths (1.8%) in the annual-screening group, 237 of the 11,004 deaths (2.2%) in the biennial-screening group, and 295 of the 10,944 deaths (2.7%) in the control group. Screening reduced colorectal-cancer mortality (relative risk with annual screening, 0.68; 95% confidence interval [CI], 0.56 to 0.82; relative risk with biennial screening, 0.78; 95% CI, 0.65 to 0.93) through 30 years of follow-up. No reduction was observed in all-cause mortality (relative risk with annual screening, 1.00; 95% CI, 0.99 to 1.01; relative risk with biennial screening, 0.99; 95% CI, 0.98 to 1.01). The reduction in colorectal-cancer mortality was larger for men than for women in the biennial-screening group (P=0.04 for interaction).

conclusionsThe effect of screening with fecal occult-blood testing on colorectal-cancer mortality persists after 30 years but does not influence all-cause mortality. The sustained reduction in colorectal-cancer mortality supports the effect of polypectomy. (Funded by the Veterans Affairs Merit Review Award Program and others.).

Indexed as

Early Detection of CancerOccult BloodAdenomaAgedAged, 80 and overColonic PolypsColorectal NeoplasmsFemaleFollow-Up StudiesHumansKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisRiskSex Factors

Identifiers

PMID24047060
OpenAlexW2066194774

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.