ArticleBiology letters2013
Prenatal exposure to testosterone impairs oxidative damage repair efficiency in the domestic chicken (Gallus gallus).
Article in Biology letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Do Egg Hormones Have Fitness Consequences in Wild Birds? A Systematic Review and Meta-Analysis.Ecology letters · 2025Pooled it
- DNA Methylation Associates With Sex-Specific Effects of Experimentally Increased Yolk Testosterone in Wild Nestlings.Molecular ecology · 2025Article
- Oxytocin prevents dysregulation of the acute stress response and glucocorticoid-induced oxidative stress in chronically isolated prairie voles.Psychoneuroendocrinology · 2023Article
- Effects of a Saccharomyces cerevisiae fermentation product-supplemented diet on fecal characteristics, oxidative stress, and blood gene expression of adult dogs undergoing transport stress.Journal of animal science · 2023Article
- Maternal testosterone affects offspring telomerase activity in a long-lived seabird.Ecology and evolution · 2022Article
- Effects of prenatal testosterone on cumulative markers of oxidative damage to organs of young adult zebra finches (Taeniopygia guttata).Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2022Article
- Natural variation in yolk fatty acids, but not androgens, predicts offspring fitness in a wild bird.Frontiers in zoology · 2021Article
- Developmental programming: Metabolic tissue-specific changes in endoplasmic reticulum stress, mitochondrial oxidative and telomere length status induced by prenatal testosterone excess in the female sheep.Molecular and cellular endocrinology · 2021Article
- Hyperandrogenemia alters mitochondrial structure and function in the oocytes of obese mouse with polycystic ovary syndrome.F&S science · 2021Article
- Is there an oxidative cost of acute stress? Characterization, implication of glucocorticoids and modulation by prior stress experience.Proceedings. Biological sciences · 2019Article
- Oxidative stress and mitochondrial responses to stress exposure suggest that king penguins are naturally equipped to resist stress.Scientific reports · 2019Article
- Revisiting mechanisms and functions of prenatal hormone-mediated maternal effects using avian species as a model.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- Article
- Co-adjustment of yolk antioxidants and androgens in birds.Biology letters · 2016Article
- Embryonic and postnatal telomere length decrease with ovulation order within clutches.Scientific reports · 2016Article
- Starting with a handicap: effects of asynchronous hatching on growth rate, oxidative stress and telomere dynamics in free-living great tits.Oecologia · 2015Article
- Voluntary locomotor activity mitigates oxidative damage associated with isolation stress in the prairie vole (Microtus ochrogaster).Biology letters · 2015Article
- Experimental food restriction reveals individual differences in corticosterone reaction norms with no oxidative costs.PloS one · 2014Article
- Prenatal exposure to testosterone impairs oxidative damage repair efficiency in the domestic chicken (Gallus gallus).Biology letters · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Elevated levels of maternal androgens in avian eggs affect numerous traits, including oxidative stress. However, current studies disagree as to whether prenatal androgen exposure enhances or ameliorates oxidative stress. Here, we tested how prenatal testosterone exposure affects oxidative stress in female domestic chickens (Gallus gallus) during the known oxidative challenge of an acute stressor. Prior to incubation, eggs were either injected with an oil vehicle or 5 ng testosterone. At either 17 or 18 days post-hatch, several oxidative stress markers were assessed from blood taken before and after a 20 min acute stressor, as well as following a 25 min recovery from the stressor. We found that, regardless of yolk treatment, during both stress and recovery all individuals were in a state of oxidative stress, with elevated levels of oxidative damage markers accompanied by a reduced total antioxidant capacity. In addition, testosterone-exposed individuals exhibited poorer DNA damage repair efficiencies in comparison with control individuals. Our work suggests that while yolk androgens do not alter oxidative stress directly, they may impair mechanisms of oxidative damage repair.
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