ArticleInternational journal of medical sciences2013
The ratio of second to fourth digit length (2D:4D) and coronary artery disease in a Han Chinese population.
Article in International journal of medical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Second to Fourth Digit Ratio (2D:4D) in Hypertension Disease.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Prenatal exposure to air pollutants and the second to fourth digit ratio in adult women.Scientific reports · 2024Article
- Are the digit ratio (2D:4D) and hand grip strength related to Parkinson disease in elderly males?BMC sports science, medicine & rehabilitation · 2023Article
- The association between second to fourth digit ratio, reproductive and general health among women: findings from an Israeli pregnancy cohort.Scientific reports · 2020Article
- Clinical Application of Mathematical Long Bone Ratios to Calculate Appropriate Donor Limb Lengths in Bilateral Upper Limb Transplantation.Hand (New York, N.Y.) · 2019Article
- 2D:4D Ratio Differs in Ischemic Stroke: A Single Center Experience.Translational neuroscience · 2018Article
- Genomic conflicts and sexual antagonism in human health: insights from oxytocin and testosterone.Evolutionary applications · 2015Review
- The second to fourth digit ratio (2D:4D): a risk factor of migraine and tension-type headache.The journal of headache and pain · 2015Article
- Second to fourth digit ratio is a predictor of sporting ability in elite Indian male kabaddi players.Asian journal of sports medicine · 2014Article
Corrections and comments
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe association between index finger to ring finger length ratio (2D:4D) and cardiac disorders has been reported, however it has not been discussed in terms of coronary artery disease (CAD). We investigated whether 2D:4D could be used as a marker for predisposition to CAD as assessed by coronary angiography in Chinese men and women.
methodsThis study included 1764 persons divided into 4 groups, 441 cases with CAD and 441 persons without CAD as control in each sex of the same age. Finger lengths were measured twice for both hands using electronic calipers. Student t test was used to detect the difference of 2D:4D among groups. The receiver operator characteristic curves (ROCs) were used to detect the diagnostic effect of 2D:4D for CAD.
resultsThere were no significant differences in age among the four groups. A significant difference of 2D:4D ratios between right and left hand were observed only in men in both control and CAD groups. On the right hand in the control group and on both hands in the CAD group, the 2D:4D ratios were higher in women than in men (all, P < 0.001). In men with CAD, mean 2D:4D was higher than mean 2D:4D in control men (right hand 0.962±0.042:0.927±0.038; left hand 0.950±0.044:0.934±0.048; both hands, P < 0.001), but this was not observed in women. No relationship was found between 2D:4D and age (all, P >0.05). The area under the curve of right hand 2D:4D in male was 0.72 (95% CI 0.683-0.753, p<0.001), while it was 0.602 (95% CI 0.565-0.639, p<0.001) in left hand.
conclusionsThe present study showed an association between high 2D:4D ratio and CAD in both hands in men. There were no significant differences in mean 2D:4D between women with CAD and controls.
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