ArticleAnnals of surgical oncology2013
Extrathoracic location and "borderline" histology are associated with recurrence of solitary fibrous tumors after surgical resection.
Article in Annals of surgical oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 64 citations in OpenAlex.
- Clinical characteristics and management of renal solitary fibrous tumors: a narrative review with literature-derived case evidence.Frontiers in oncology · 2026Review
- Robot-assisted laparoscopic prostate-sparing resection of an extremely rare periprostatic solitary fibrous tumor: a case report and literature review.World journal of surgical oncology · 2025Review
- Article
- Risk factors for recurrent disease after resection of solitary fibrous tumor: a systematic review.Frontiers in surgery · 2024Review
- Clinicopathologic characterization and assessment of prognostic factors for intraabdominal solitary fibrous tumors involving the gastrointestinal tract and liver.Virchows Archiv : an international journal of pathology · 2022Article
- Novel Therapeutic Options for Solitary Fibrous Tumor: Antiangiogenic Therapy and Beyond.Cancers · 2022Review
- Solitary fibrous tumor of the greater omentum: case report and review of literature.Surgical case reports · 2021Article
- Laparoscopic excision of a solitary fibrous tumor originating from the abdominal wall: a case report.Journal of surgical case reports · 2021Article
- Preoperative Embolization of a Solitary Fibrous Tumor Originating from External Auditory Meatus: A Case Report with Literature Review.Diagnostics (Basel, Switzerland) · 2021Article
- Doege-Potter syndrome by malignant solitary fibrous tumor of the liver: A case report and review of literature.World journal of gastrointestinal surgery · 2019Article
- Solitary fibrous tumor of the pineal region with delayed ectopic intracranial metastasis: A case report and review of the literature.Medicine · 2019Article
- Solitary fibrous tumor in the liver: case report and literature review.Surgical case reports · 2019Article
- Sinonasal Tract Solitary Fibrous Tumor: A Clinicopathologic Study of Six Cases with a Comprehensive Review of the Literature.Head and neck pathology · 2018Review
- Article
- Solitary fibrous tumor of the abdominal wall re-surfacing as unilateral pleural effusion and mass: A case report and review of the literature.Respiratory medicine case reports · 2018Article
- Risk assessment in solitary fibrous tumors: validation and refinement of a risk stratification model.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2017Article
- Article
- Metastatic extrapleural malignant solitary fibrous tumor presenting with hypoglycemia (Doege-Potter syndrome).Radiology case reports · 2017Article
- TERT promoter mutations and prognosis in solitary fibrous tumor.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2016Article
- Solitary Fibrous Tumor of the Liver: a Review of the Current Knowledge and Report of a New Case.Journal of gastrointestinal cancer · 2015Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMost solitary fibrous tumors (SFTs) are cured by complete resection, but many recurrent and metastatic SFTs do not respond to treatment and are fatal. Malignant histology, defined by England's pathologic criteria, is strongly associated with recurrence, but some benign SFTs still behave aggressively. Several studies have suggested that extrathoracic SFTs have a worse prognosis. We reviewed thoracic and extrathoracic SFTs from our institution to determine if extrathoracic location is associated with recurrence, independent of malignant histology.
methodsWith IRB approval, we retrieved patient pathology reports from the Johns Hopkins Surgical Pathology database between 1991 and 2011 and included 83 SFT patients in our analysis. Patient history and outcomes were obtained from the medical record and primary care physicians. Predictors of recurrence were analyzed by univariate and multivariate analysis and survival determined by the Kaplan-Meier method.
resultsOf the 83 patients, 59 had extrathoracic SFTs in neurologic (n = 24), extremity or head/neck (n = 13), or visceral/intraabdominal (n = 22) sites. A total of 74 SFTs were classified benign and 9 as malignant. Of the 14 recurrences, 13 occurred in extrathoracic SFTs; only 7 were classified as malignant. Multivariate analysis confirmed that malignant histology had the strongest association with recurrence, but extrathoracic location also independently predicted recurrence. A total of 20 benign SFTs possessed 1 or more of England's criteria but to an insufficient degree for malignant classification. These "borderline" SFTs were more likely to recur than benign SFTs without these features.
conclusionsExtrathoracic and "borderline" SFTs with any of England's criteria have a higher risk of recurrence.
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