ArticleCerebral cortex (New York, N.Y. : 1991)2015
Environmental enrichment reveals effects of genotype on hippocampal spine morphologies in the mouse model of Fragile X Syndrome.
Article in Cerebral cortex (New York, N.Y. : 1991), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- Fmr1-KO mice failure to detect object novelty associates with a post-test decrease of structural and synaptic plasticity upstream of the hippocampus.Scientific reports · 2023Article
- Spaced training improves learning in Ts65Dn and Ube3a mouse models of intellectual disabilities.Translational psychiatry · 2019Article
- Reward-Related Expectations Trigger Dendritic Spine Plasticity in the Mouse Ventrolateral Orbitofrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Exercising New Neurons to Vanquish Alzheimer Disease.Brain plasticity (Amsterdam, Netherlands) · 2018Review
- Unique Sensory and Motor Behavior in Thy1-GFP-M Mice before and after Spinal Cord Injury.Journal of neurotrauma · 2018Article
- Imbalance of synaptic actin dynamics as a key to fragile X syndrome?The Journal of physiology · 2018Review
- Experiential learning in rodents: past experience enables rapid learning and localized encoding in hippocampus.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Parameters for abolishing conditioned place preference for cocaine from running and environmental enrichment in male C57BL/6J mice.Behavioural brain research · 2016Article
- Chronic Ampakine Treatments Stimulate Dendritic Growth and Promote Learning in Middle-Aged Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Specific effect of the fragile-X mental retardation-1 gene (FMR1) on white matter microstructure.The British journal of psychiatry : the journal of mental science · 2015Article
- Early social enrichment rescues adult behavioral and brain abnormalities in a mouse model of fragile X syndrome.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Fmr1 KO and fenobam treatment differentially impact distinct synapse populations of mouse neocortex.Neuron · 2014Article
- Genetic removal of matrix metalloproteinase 9 rescues the symptoms of fragile X syndrome in a mouse model.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- The contribution of inhibitory interneurons to circuit dysfunction in Fragile X Syndrome.Frontiers in cellular neuroscience · 2014Review
- Impaired activity-dependent neural circuit assembly and refinement in autism spectrum disorder genetic models.Frontiers in cellular neuroscience · 2014Review
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Fragile X Syndrome (FXS) and the Fmr1 knockout (KO) mouse model of this disorder exhibit abnormal dendritic spines in neocortex, but the degree of spine disturbances in hippocampus is not clear. The present studies tested if the mutation influences dendritic branching and spine measures for CA1 pyramidal cells in Fmr1 KO and wild-type (WT) mice provided standard or enriched environment (EE) housing. Automated measures from 3D reconstructions of green fluorescent protein (GFP)-labeled cells showed that spine head volumes were ∼ 40% lower in KOs when compared with WTs in both housing conditions. With standard housing, average spine length was greater in KOs versus WTs but there was no genotype difference in dendritic branching, numbers of spines, or spine length distribution. However, with EE rearing, significant effects of genotype emerged including greater dendritic branching in WTs, greater spine density in KOs, and greater numbers of short thin spines in KOs when compared with WTs. Thus, EE rearing revealed greater effects of the Fmr1 mutation on hippocampal pyramidal cell morphology than was evident with standard housing, suggesting that environmental enrichment allows for fuller appreciation of the impact of the mutation and better representation of abnormalities likely to be present in human FXS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.