Evidence map›Paper›PMID 24045907›Full record

ArticleJournal of the American Medical Informatics Association : JAMIA

Predicting changes in hypertension control using electronic health records from a chronic disease management program.

Jimeng Sun, Candace D McNaughton, Ping Zhang, Adam Perer, Aris Gkoulalas-Divanis, Joshua C Denny, Jacqueline Kirby, Thomas Lasko, Alexander Saip, Bradley A Malin

Abstract read
In one paragraph

Article in Journal of the American Medical Informatics Association : JAMIA. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  7. Review
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  11. CaliForest: Calibrated Random Forest for Health Data.Proceedings of the ACM Conference on Health, Inference, and Learning · 2020
    Article
  12. Article
  13. Synthesizing electronic health records using improved generative adversarial networks.Journal of the American Medical Informatics Association : JAMIA · 2019
    Article
  14. Learning to Identify Patients at Risk of Uncontrolled Hypertension Using Electronic Health Records Data.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2019
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  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jimeng SunHealthcare Analytics, IBM TJ Watson Research Center, Yorktown Heights, New York, USA.
Candace D McNaughton
Ping Zhang
Adam Perer
Aris Gkoulalas-Divanis
Joshua C Denny
Jacqueline Kirby
Thomas Lasko
Alexander Saip
Bradley A Malin

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
National Infrastructure for Standardized and Portable EHR Phenotyping AlgorithmsR01GM105688 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI LUO, YUAN, PATHAK, JYOTISHMAN · 2013 to 2020
$5.7M
The Vanderbilt Emergency Medicine Research Training Program (VEMRT)K12HL109019 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COLLINS, SEAN PATRICK, STORROW, ALAN B · 2011 to 2015
$3.7M
NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1TR000445NHLBI NIH HHS K12 HL109019NHLBI NIH HHS K12HL109019
6 · The paper itself

Abstract

objectiveCommon chronic diseases such as hypertension are costly and difficult to manage. Our ultimate goal is to use data from electronic health records to predict the risk and timing of deterioration in hypertension control. Towards this goal, this work predicts the transition points at which hypertension is brought into, as well as pushed out of, control.

methodIn a cohort of 1294 patients with hypertension enrolled in a chronic disease management program at the Vanderbilt University Medical Center, patients are modeled as an array of features derived from the clinical domain over time, which are distilled into a core set using an information gain criteria regarding their predictive performance. A model for transition point prediction was then computed using a random forest classifier.

resultsThe most predictive features for transitions in hypertension control status included hypertension assessment patterns, comorbid diagnoses, procedures and medication history. The final random forest model achieved a c-statistic of 0.836 (95% CI 0.830 to 0.842) and an accuracy of 0.773 (95% CI 0.766 to 0.780).

conclusionsThis study achieved accurate prediction of transition points of hypertension control status, an important first step in the long-term goal of developing personalized hypertension management plans.

Indexed as

Disease ManagementElectronic Health RecordsAntihypertensive AgentsChronic DiseaseHumansHypertensionModels, TheoreticalPrognosisAntihypertensive Agentshypertension controlpredictive modelingvisualization

Identifiers

PMID24045907
PMCPMC3932462

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.