Evidence map›Paper›PMID 24045867›Full record

Trial reportAmerican journal of physiology. Endocrinology and metabolism2013

Pancreatic β-cell function increases in a linear dose-response manner following exercise training in adults with prediabetes.

Steven K Malin, Thomas P J Solomon, Alecia Blaszczak, Stephen Finnegan, Julianne Filion, John P Kirwan

Open access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of physiology. Endocrinology and metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 2 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 91 citations in OpenAlex.

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  5. β-Cell function during a high-fat meal in young versus old adults: role of exercise.American journal of physiology. Regulatory, integrative and comparative physiology · 2023
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  16. Tailoring Exercise Prescription for Effective Diabetes Glucose Management.The Journal of clinical endocrinology and metabolism · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Steven K MalinDepartment of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio;
Thomas P J Solomon
Alecia Blaszczak
Stephen Finnegan
Julianne Filion
John P Kirwan
Cleveland Clinic Lerner College of Medicine · USCase Western Reserve University · USRigshospitalet · DK

Funding

Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
TRAINING IN METABOLISMT32DK007319 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI BRUNENGRABER, HENRI · 1986 to 2013
$5.0M
Age, Exercise, Diet: Effects on Insulin ResistanceR01AG012834 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI KIRWAN, JOHN P. · 2004 to 2008
$1.9M
NCATS NIH HHS UL1 TR000439NIA NIH HHS R01-AG-12834NIDDK NIH HHS T32-DK-007319
6 · The paper itself

Abstract

Although some studies suggest that a linear dose-response relationship exists between exercise and insulin sensitivity, the exercise dose required to enhance pancreatic β-cell function is unknown. Thirty-five older obese adults with prediabetes underwent a progressive 12-wk supervised exercise intervention (5 days/wk for 60 min at ~85% HRmax). Insulin and C-peptide responses to an OGTT were used to define the first- and second-phase disposition index (DI; β-cell function = glucose-stimulated insulin secretion × clamp-derived insulin sensitivity). Maximum oxygen consumption (Vo2max) and body composition (dual-energy X-ray absorptiometry and computed tomography) were also measured before and after the intervention. Exercise dose was computed using Vo2/heart-rate derived linear regression equations. Subjects expended 474.5 ± 8.8 kcal/session (2,372.5 ± 44.1 kcal/wk) during the intervention and lost ~8% body weight. Exercise increased first- and second-phase DI (P < 0.05), and these changes in DI were linearly related to exercise dose (DIfirst phase: r = 0.54, P < 0.001; DIsecond phase: r = 0.56, P = 0.0005). Enhanced DI was also associated with increased Vo2max (DIfirst phase: r = 0.36, P = 0.04; DIsecond phase: r = 0.41, P < 0.02) but not lower body fat (DIfirst phase: r = -0.21, P = 0.25; DIsecond phase: r = -0.30, P = 0.10) after training. Low baseline DI predicted an increase in DI after the intervention (DIfirst phase: r = -0.37; DIsecond phase: r = -0.41, each P < 0.04). Thus, exercise training plus weight loss increased pancreatic β-cell function in a linear dose-response manner in adults with prediabetes. Our data suggest that higher exercise doses (i.e., >2,000 kcal/wk) are necessary to enhance β-cell function in adults with poor insulin secretion capacity.

Indexed as

AdultAgedExerciseFemaleHumansInsulin-Secreting CellsLinear ModelsMaleMiddle AgedOxygen ConsumptionPhysical Education and TrainingPrediabetic StateTime FactorsWeight Lossagingglucose intoleranceinsulin resistanceobesitytype 2 diabetes

Identifiers

PMID24045867
PMCPMC3840210
OpenAlexW2065590498

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.