ArticleNature communications2013
The tiger genome and comparative analysis with lion and snow leopard genomes.
Article in Nature communications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 130 papers.
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Who cites it
130 citing papers in PubMed, 325 citations in OpenAlex.
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- Genome-Wide Analysis Successfully Resolves Population Structure Shaped by Recent Divergence in the Endangered Bagrid CatfishEcology and evolution · 2026Article
- Conservation genomics highlights the urgency of protecting Indo-Pacific humpback dolphins (Sousa chinensis) in Chinese waters.Science China. Life sciences · 2026Article
- Predicting extinction risk of gibbons from genomes of extinct Yunnan lar gibbon.Genome biology · 2026Article
- The Japanese Archipelago sheltered cave lions, not tigers, during the Late Pleistocene.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Exploring the genetic footprints of high altitude adapted humans and livestock.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Review
- Exceedingly low genetic diversity in snow leopards due to persistently small population size.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Simultaneous voltage-gated control of ion and water transport in ZrNature communications · 2025Article
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- Genomic evidence for low genetic diversity but purging of strong deleterious variants in snow leopards.Genome biology · 2025Article
- Genomic insights and the conservation potential of captive breeding: The case of Chinese alligator.Science advances · 2025Article
- Parameterizing Pantherinae: De Novo Mutation Rate Estimates from Panthera and Neofelis Pedigrees.Genome biology and evolution · 2025Article
- Purging of Highly Deleterious Mutations Through an Extreme Bottleneck.Molecular biology and evolution · 2025Article
- CRISPR/Cas9-mediated CH2 deletion of Fel d1 triggers transcriptomic reprogramming and disease-associated pathways in feline cells.Frontiers in cell and developmental biology · 2025Article
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- Genetic diversity of the major cat allergen, Fel d 1.PNAS nexus · 2024Article
- Genomic adaptation to small population size and saltwater consumption in the critically endangered Cat Ba langur.Nature communications · 2024Article
70 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
58 authors at 20 institutions in 10 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tigers and their close relatives (Panthera) are some of the world's most endangered species. Here we report the de novo assembly of an Amur tiger whole-genome sequence as well as the genomic sequences of a white Bengal tiger, African lion, white African lion and snow leopard. Through comparative genetic analyses of these genomes, we find genetic signatures that may reflect molecular adaptations consistent with the big cats' hypercarnivorous diet and muscle strength. We report a snow leopard-specific genetic determinant in EGLN1 (Met39>Lys39), which is likely to be associated with adaptation to high altitude. We also detect a TYR260G>A mutation likely responsible for the white lion coat colour. Tiger and cat genomes show similar repeat composition and an appreciably conserved synteny. Genomic data from the five big cats provide an invaluable resource for resolving easily identifiable phenotypes evident in very close, but distinct, species.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.