Trial reportEuropean journal of nutrition2014
The impact of protein supplementation on cognitive performance in frail elderly.
Trial report in European journal of nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- The Effects of Cow-Milk Protein Supplementation in Elderly Population: Systematic Review and Narrative Synthesis.Nutrients · 2020Pooled it
- The Impact of Dietary Factors on Indices of Chronic Disease in Older People: A Systematic Review.The journal of nutrition, health & aging · 2018Pooled it
- Nutrition support in hospitalised adults at nutritional risk.The Cochrane database of systematic reviews · 2017Pooled it
- Nutrition and Dementia: Evidence for Preventive Approaches?Nutrients · 2016Pooled it
- Long-term effects of an egg-protein hydrolysate on cognitive performance and brain vascular function: a double-blind randomized controlled trial in adults with elevated subjective cognitive failures.European journal of nutrition · 2024Trial
- Trial
- Trial
- The association between total, animal-based, and plant-based protein intake and cognitive decline in older adults.European journal of nutrition · 2025Article
- Association of Low Protein-to-Carbohydrate Energy Ratio with Cognitive Impairment in Elderly Type 2 Diabetes Patients.Nutrients · 2024Article
- Article
- Article
- Interactive Effects of Methionine and Lead Intake on Cognitive Function among Chinese Adults.Nutrients · 2022Article
- Markers of a plant-based diet relate to memory and executive function in older adults.Nutritional neuroscience · 2022Article
- Short-term protein restriction at advanced age stimulates FGF21 signalling, energy expenditure and browning of white adipose tissue.The FEBS journal · 2021Article
- Association between Dietary Protein Intake and Cognitive Function in Adults Aged 60 Years and Older.The journal of nutrition, health & aging · 2020Article
- Intake of Seven Essential Amino Acids Improves Cognitive Function and Psychological and Social Function in Middle-Aged and Older Adults: A Double-Blind, Randomized, Placebo-Controlled Trial.Frontiers in nutrition · 2020Article
- Dietary Protein, Exercise, and Frailty Domains.Nutrients · 2019Review
- The association of protein and carbohydrate intake with successful aging: a combined analysis of two epidemiological studies.European journal of nutrition · 2019Article
- Nutritional Interventions for Elderly and Considerations for the Development of Geriatric Foods.Current aging science · 2019Review
- No Tryptophan, Tyrosine and Phenylalanine Abnormalities in Children with Attention-Deficit/Hyperactivity Disorder.PloS one · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMaintenance of cognitive abilities is important for elderly to stay independent. With the aging of the population, the call for modifiable factors is emerging. Dietary protein might improve cognitive performance; however, this has hardly been studied. Therefore, we studied the impact of 24-week dietary protein supplementation on cognitive performance in pre-frail and frail elderly people.
methodsPre-frail and frail elderly subjects, according to the Fried criteria, randomly received a protein drink containing 15 g protein or a placebo drink twice a day. Cognitive performance was measured at baseline and after 24 weeks by means of a sensitive neuropsychological test battery. In addition, reaction time was assessed after both 12 and 24 weeks of intervention. Domain scores were calculated for the domains episodic memory, attention and working memory, information processing speed, and executive functioning. Analyses of covariance were used to determine differences between groups. Linear mixed models were used to determine differences in reaction time over time and per treatment.
resultsIn total, 65 subjects (79 ± 8 years) with a median Mini-Mental State Examination score of 28 (interquartile range 26-30) were included. Reaction time improved more in the protein group (68 ms) than in the placebo group (18 ms, P = 0.03). Dietary protein had no significant effect on any of the cognitive domain scores.
conclusionsProtein supplementation might improve reaction time performance in pre-frail and frail elderly, but did not improve other cognitive functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.