Evidence map›Paper›PMID 24045673›Full record

Trial reportMenopause (New York, N.Y.)2014

Efficacy of yoga for vasomotor symptoms: a randomized controlled trial.

Katherine M Newton, Susan D Reed, Katherine A Guthrie, Karen J Sherman, Cathryn Booth-LaForce, Bette Caan, Barbara Sternfeld, Janet S Carpenter, Lee A Learman, Ellen W Freeman and 7 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Menopause (New York, N.Y.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 11 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 11 syntheses or guidelines pooled it, 146 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Pooled it
  5. Pooled it
  6. Variation in menopausal vasomotor symptoms outcomes in clinical trials: a systematic review.BJOG : an international journal of obstetrics and gynaecology · 2020
    Pooled it
  7. Pooled it
  8. Pooled it
  9. Survivorship, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology.Journal of the National Comprehensive Cancer Network : JNCCN · 2017
    Guideline
  10. Exercise for vasomotor menopausal symptoms.The Cochrane database of systematic reviews · 2014
    Pooled it
  11. Pooled it
  12. Trial
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  15. Trial
  16. Effects of Yoga and Aerobic Exercise on Actigraphic Sleep Parameters in Menopausal Women with Hot Flashes.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2017
    Trial
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 9 institutions in 2 countries.

Katherine M NewtonFrom the 1Group Health Research Institute, Seattle, WA; 2Departments of Obstetrics/Gynecology and Epidemiology, University of Washington School of Medicine, Seattle, WA; 3Data Coordinating Center, Fred Hutchinson Cancer Research Center, Seattle, WA; 4School of Nursing, University of Washington, Seattle, WA; 5Division of Research, Kaiser Permanente Medical Program of Northern California, Oakland, CA; 6School of Nursing, Indiana University, Indianapolis, IN; 7Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN; 8Department of Obstetrics/Gynecology, University of Pennsylvania, Philadelphia, PA; 9Massachusetts General Hospital, Boston, MA; 10Department of Medicine, VA Medical Center, Minneapolis, MN; and 11Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN.
Susan D Reed
Katherine A Guthrie
Karen J Sherman
Cathryn Booth-LaForce
Bette Caan
Barbara Sternfeld
Janet S Carpenter
Lee A Learman
Ellen W Freeman
Lee S Cohen
Hadine Joffe
Garnet L Anderson
Joseph C Larson
Julie R Hunt
Kristine E Ensrud
Andrea Z LaCroix
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa · ZAGroup Health Cooperative · USHarvard University Press · USKaiser Permanente · USUniversity of Washington · USCalifornia University of Pennsylvania · USIndiana University Bloomington · USIndiana University School of MedicineUniversity of Minnesota System · US

Funding

Menopausal Symptoms Initiative-Finding Lasting Answers for Sweats and Hot FlashesU01AG032699 · NIA · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GUTHRIE, KATHERINE ADAMS, LACROIX, ANDREA Z. · 2008 to 2012
$13.5M
Center for Clinical and Translational Sciences (CCTS)UL1TR000371 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2012 to 2016
$13.4M
MsFLASH: Living a Healthy MenopauseR01AG048209 · NIA · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GUTHRIE, KATHERINE ADAMS, LACROIX, ANDREA Z. · 2015 to 2019
$7.2M
MSI-FLASH: Relative Efficacy of Hormonal and Non-Hormonal Interventions for VMSU01AG032700 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI COHEN, LEE S, JOFFE, HADINE · 2008 to 2012
$1.7M
MSI FLASH: An RCT of Yoga and Ultra Low-Dose Estrogen Gel for Vasomotor SymptomsU01AG032682 · NIA · KAISER FOUNDATION HEALTH PLAN OF WASHINGTON · PI NEWTON, KATHERINE M. · 2008 to 2012
$1.7M
Efficacy of an SSRI for Menopausal Symptoms in Perimenopausal WomenU01AG032656 · NIA · UNIVERSITY OF PENNSYLVANIA · PI FREEMAN, ELLEN W · 2008 to 2012
$1.5M
MSI-FLASH: Paced Respiration for Breast Cancer SurvivorsU01AG032659 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI CARPENTER, JANET S · 2008 to 2012
$1.5M
MSI-FLASH: An Exercise Intervention for Women with Menopausal SymptomsU01AG032669 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI CAAN, BETTE J · 2008 to 2012
$1.5M
NCATS NIH HHS UL1 TR000371NCRR NIH HHS UL1RR02571NIA NIH HHS R01 AG048209NIA NIH HHS U01 AG032656NIA NIH HHS U01AG032656NIA NIH HHS U01 AG032659NIA NIH HHS U01AG032659NIA NIH HHS U01 AG032669NIA NIH HHS U01AG032669NIA NIH HHS U01 AG032682NIA NIH HHS U01AG032682NIA NIH HHS U01 AG032699NIA NIH HHS U01AG032699NIA NIH HHS U01 AG032700NIA NIH HHS U01AG032700
6 · The paper itself

Abstract

objectiveThis study aims to determine the efficacy of yoga in alleviating vasomotor symptoms (VMS) frequency and bother.

methodsThis study was a three-by-two factorial, randomized controlled trial. Eligible women were randomized to yoga (n = 107), exercise (n = 106), or usual activity (n = 142), and were simultaneously randomized to a double-blind comparison of ω-3 fatty acid (n = 177) or placebo (n = 178) capsules. Yoga intervention consisted of 12 weekly 90-minute yoga classes with daily home practice. Primary outcomes were VMS frequency and bother assessed by daily diaries at baseline, 6 weeks, and 12 weeks. Secondary outcomes included insomnia symptoms (Insomnia Severity Index) at baseline and 12 weeks.

resultsAmong 249 randomized women, 237 (95%) completed 12-week assessments. The mean baseline VMS frequency was 7.4 per day (95% CI, 6.6 to 8.1) in the yoga group and 8.0 per day (95% CI, 7.3 to 8.7) in the usual activity group. Intent-to-treat analyses included all participants with response data (n = 237). There was no difference between intervention groups in the change in VMS frequency from baseline to 6 and 12 weeks (mean difference [yoga--usual activity] from baseline at 6 wk, -0.3 [95% CI, -1.1 to 0.5]; mean difference [yoga--usual activity] from baseline at 12 wk, -0.3 [95% CI, -1.2 to 0.6]; P = 0.119 across both time points). Results were similar for VMS bother. At week 12, yoga was associated with an improvement in insomnia symptoms (mean difference [yoga - usual activity] in the change in Insomnia Severity Index, 1.3 [95% CI, -2.5 to -0.1]; P = 0.007).

conclusionsAmong healthy women, 12 weeks of yoga class plus home practice, compared with usual activity, do not improve VMS frequency or bother but reduce insomnia symptoms.

Indexed as

MenopauseYogaAnxietyDepressionDouble-Blind MethodExerciseFemaleHot FlashesHumansMeditationMiddle AgedSleep Initiation and Maintenance DisordersTreatment Outcome

Identifiers

PMID24045673
PMCPMC3871975
OpenAlexW2140449138

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.