ArticleBritish journal of cancer2013
Iodine-131 dose-dependent gene expression: alterations in both normal and tumour thyroid tissues of post-Chernobyl thyroid cancers.
Article in British journal of cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Somatic health effects of Chernobyl: 30 years on.European journal of epidemiology · 2017Pooled it
- Post-Chornobyl thyroid papillary carcinomas display distinct pastScientific reports · 2026Article
- Regulatory networks of iron sulfur cluster biology in cancer mechanisms and therapeutic perspectives.iScience · 2026Review
- Radiation-Related Thyroid Cancer.Endocrine reviews · 2024Review
- Age-related long-term response in rat thyroid tissue and plasma after internal low dose exposure toScientific reports · 2022Article
- Susceptibility Genes and Chromosomal Regions Associated With Non-Syndromic Familial Non-Medullary Thyroid Carcinoma: Some Pathogenetic and Diagnostic Keys.Frontiers in endocrinology · 2022Review
- Consequences of atmospheric contamination by radioiodine: the Chernobyl and Fukushima accidents.Endocrine · 2021Review
- Utility of gene expression studies in relation to radiation exposure and clinical outcomes: thyroid cancer in the Ukrainian-American cohort and late health effects in a MAYAK worker cohort.International journal of radiation biology · 2021Review
- Precursor and borderline lesions of the thyroid (indolent lesions of epithelial origin): from theory to practice.Gland surgery · 2020Review
- Transcriptome network of the papillary thyroid carcinoma radiation marker CLIP2.Radiation oncology (London, England) · 2020Article
- Identification of potential novel biomarkers to differentiate malignant thyroid nodules with cytological indeterminate.BMC cancer · 2020Article
- Long-term transcriptomic and proteomic effects in Sprague Dawley rat thyroid and plasma after internal low dose 131I exposure.PloS one · 2020Article
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- Article
- Gene signature of the post-Chernobyl papillary thyroid cancer.European journal of nuclear medicine and molecular imaging · 2016Article
- Genomic copy number analysis of Chernobyl papillary thyroid carcinoma in the Ukrainian-American Cohort.Carcinogenesis · 2015Article
- Dose-dependent expression of CLIP2 in post-Chernobyl papillary thyroid carcinomas.Carcinogenesis · 2015Article
- Article
- Association of the miR-149 Rs2292832 polymorphism with papillary thyroid cancer risk and clinicopathologic characteristics in a Chinese population.International journal of molecular sciences · 2014Article
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Authors and funding
10 authors at 5 institutions in 4 countries.
Funding
Abstract
backgroundA strong, consistent association between childhood irradiation and subsequent thyroid cancer provides an excellent model for studying radiation carcinogenesis.
methodsWe evaluated gene expression in 63 paired RNA specimens from frozen normal and tumour thyroid tissues with individual iodine-131 (I-131) doses (0.008-8.6 Gy, no unirradiated controls) received from Chernobyl fallout during childhood (Ukrainian-American cohort). Approximately half of these randomly selected samples (32 tumour/normal tissue RNA specimens) were hybridised on 64 whole-genome microarrays (Agilent, 4 × 44 K). Associations between I-131 dose and gene expression were assessed separately in normal and tumour tissues using Kruskal-Wallis and linear trend tests. Of 155 genes significantly associated with I-131 after Bonferroni correction and with ≥2-fold increase per dose category, we selected 95 genes. On the remaining 31 RNA samples these genes were used for validation purposes using qRT-PCR.
resultsExpression of eight genes (ABCC3, C1orf9, C6orf62, FGFR1OP2, HEY2, NDOR1, STAT3, and UCP3) in normal tissue and six genes (ANKRD46, CD47, HNRNPH1, NDOR1, SCEL, and SERPINA1) in tumour tissue was significantly associated with I-131. PANTHER/DAVID pathway analyses demonstrated significant over-representation of genes coding for nucleic acid binding in normal and tumour tissues, and for p53, EGF, and FGF signalling pathways in tumour tissue.
conclusionThe multistep process of radiation carcinogenesis begins in histologically normal thyroid tissue and may involve dose-dependent gene expression changes.
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