ArticleAmerican journal of clinical pathology2013
Software-automated counting of Ki-67 proliferation index correlates with pathologic grade and disease progression of follicular lymphomas.
Article in American journal of clinical pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Histologic transformation of follicular lymphoma: pathologists' viewpoint.Journal of clinical and experimental hematopathology : JCEH · 2023Review
- The prognostic index PRIMA-PI combined with Ki67 as a better predictor of progression of disease within 24 months in follicular lymphoma.Frontiers in oncology · 2023Article
- Bidirectional Mapping-Based Domain Adaptation for Nucleus Detection in Cross-Modality Microscopy Images.IEEE transactions on medical imaging · 2021Article
- Upward trend in follicular lymphoma among the Korean population: 10-year experience at a large tertiary institution.Journal of pathology and translational medicine · 2021Article
- Automated quantification of Ki-67 index associates with pathologic grade of pulmonary neuroendocrine tumors.Chinese medical journal · 2019Article
- Ki-67 expression of immunohistochemistry using computerized image analysis is a useful prognostic marker in follicular lymphomas.International journal of clinical and experimental pathology · 2018Article
- Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2017Article
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Authors and funding
9 authors.
Funding
Abstract
objectivesTo examine the accuracy of software-assisted measurement of the Ki-67 proliferation index (PI) and its correlation with the grade and clinical progression of follicular lymphoma (FL).
methodsHigh-power field equivalents were extracted from H&E- and Ki-67-immunostained slides of FL, and a nuclear quantitation algorithm was used to calculate a PI. Representative fields were manually counted for validation with close agreement.
resultsThe PI was significantly higher in World Health Organization grade 3 FL than grade 1 to 2 FL. Disease progression, as defined by subsequent treatment with radiation or cytotoxic chemotherapy, was also significantly associated with elevated PI but not pathologic grade.
conclusionsThese data show that software-automated quantitation of Ki-67 can provide both a useful adjunct to pathologic grade in FL and improved prognostic information for patients.
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