ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2014
Cerebral arterial bolus arrival time is prolonged in multiple sclerosis and associated with disability.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03896217 (A Double-blind, Randomised, Placebo-controlled Single-site Study of High Dose Simvastatin Treatment for Secondary Progressive Multiple Sclerosis), which is not on this map. Cited by 46 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Double-blind, Randomised, Placebo-controlled Single-site Study of High Dose Simvastatin Treatment for Secondary Progressive Multiple Sclerosis: Impact on Vascular Perfusion and Oxidative Damage
Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Optical coherence tomography angiography measurements in multiple sclerosis: a systematic review and meta-analysis.Journal of neuroinflammation · 2023Pooled it
- Article
- Investigating cortical hypoxia in multiple sclerosis via time-domain near-infrared spectroscopy.Annals of clinical and translational neurology · 2024Article
- Recommendations for quantitative cerebral perfusion MRI using multi-timepoint arterial spin labeling: Acquisition, quantification, and clinical applications.Magnetic resonance in medicine · 2024Review
- Contrast-free dynamic susceptibility contrast using sinusoidal and bolus oxygenation challenges.NMR in biomedicine · 2024Article
- Microglia/macrophage polarization regulates spontaneous remyelination in intermittent cuprizone model of demyelination.Biochemistry and biophysics reports · 2024Article
- Evaluation of the Vascular Network with Optical Coherens Tomography Angiography in Multiple Sclerosis and its Relationship with the Clinic.Noro psikiyatri arsivi · 2024Article
- Pathophysiology of multiple sclerosis damage and repair: Linking cerebral hypoperfusion to the development of irreversible tissue loss in multiple sclerosis using magnetic resonance imaging.European journal of neurology · 2023Article
- Article
- Using carpet plots to analyze blood transit times in the brain during hypercapnic challenge magnetic resonance imaging.Frontiers in physiology · 2023Article
- Tissue factor as a potential coagulative/vascular marker in relapsing-remitting multiple sclerosis.Frontiers in immunology · 2023Observational
- Cerebrovascular reactivity in multiple sclerosis is restored with reduced inflammation during immunomodulation.Scientific reports · 2022Article
- Characterizing the time course of cerebrovascular reactivity in multiple sclerosis.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2022Article
- Characteristics of cerebral blood flow in an Eastern sample of multiple sclerosis patients: A potential quantitative imaging marker associated with disease severity.Frontiers in immunology · 2022Article
- Examination of optimized protocols for pCASL: Sensitivity to macrovascular contamination, flow dispersion, and prolonged arterial transit time.Magnetic resonance in medicine · 2021Article
- Quantitative magnetic resonance imaging towards clinical application in multiple sclerosis.Brain : a journal of neurology · 2021Review
- Cerebral Vasoreactivity as an Indirect MRI Marker of White Matter Tracts Alterations in Multiple Sclerosis.Brain topography · 2021Article
- Mind the gap: from neurons to networks to outcomes in multiple sclerosis.Nature reviews. Neurology · 2021Review
- Blood Oxygenation Level-Dependent Response to Multiple Grip Forces in Multiple Sclerosis: Going Beyond the Main Effect of Movement in Brodmann Area 4a and 4p.Frontiers in cellular neuroscience · 2021Article
- Reliability and Reproducibility of Hadamard Encoded Pseudo-Continuous Arterial Spin Labeling in Healthy Elderly.Frontiers in neuroscience · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alterations in the overall cerebral hemodynamics have been reported in multiple sclerosis (MS); however, their cause and significance is unknown. While potential venous causes have been examined, arterial causes have not. In this study, a multiple delay time arterial spin labeling magnetic resonance imaging sequence at 3T was used to quantify the arterial hemodynamic parameter bolus arrival time (BAT) and cerebral blood flow (CBF) in normal-appearing white matter (NAWM) and deep gray matter in 33 controls and 35 patients with relapsing-remitting MS. Bolus arrival time was prolonged in MS in NAWM (1.0±0.2 versus 0.9±0.2 seconds, P=0.031) and deep gray matter (0.90±0.18 versus 0.80±0.14 seconds, P=0.001) and CBF was increased in NAWM (14±4 versus 10±2 mL/100 g/min, P=0.001). Prolonged BAT in NAWM (P=0.042) and deep gray matter (P=0.01) were associated with higher expanded disability status score. This study demonstrates alteration in cerebral arterial hemodynamics in MS. One possible cause may be widespread inflammation. Bolus arrival time was longer in patients with greater disability independent of atrophy and T2 lesion load, suggesting alterations in cerebral arterial hemodynamics may be a marker of clinically relevant pathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.