ArticleBiochemical and biophysical research communications2013
Malignant transformation of colonic epithelial cells by a colon-derived long noncoding RNA.
Article in Biochemical and biophysical research communications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
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- An Overview of the Biological Complexity of Vitiligo.Oxidative medicine and cellular longevity · 2024Review
- Identification of sex differentiation-related microRNA and long non-coding RNA in Takifugu rubripes gonads.Scientific reports · 2021Article
- The Role of lncRNAs in Gene Expression Regulation through mRNA Stabilization.Non-coding RNA · 2021Review
- Diagnostic and prognostic potential of tissue and circulating long non-coding RNAs in colorectal tumors.World journal of gastroenterology · 2019Review
- Interaction and cross-talk between non-coding RNAs.Cellular and molecular life sciences : CMLS · 2018Review
- Long non-coding RNAs act as regulators of cell autophagy in diseases (Review).Oncology reports · 2017Review
- Long non-coding RNAs in Colorectal Cancer: Progression and Future Directions.Journal of Cancer · 2017Article
- Expression and clinicopathological significance of the lncRNA HOXA11-AS in colorectal cancer.Oncology letters · 2016Article
- NEAT1 upregulates EGCG-induced CTR1 to enhance cisplatin sensitivity in lung cancer cells.Oncotarget · 2016Article
- Long Noncoding RNA in Digestive Tract Cancers: Function, Mechanism, and Potential Biomarker.The oncologist · 2015Review
- Functional interactions among microRNAs and long noncoding RNAs.Seminars in cell & developmental biology · 2014Review
- Expression profiles and initial confirmation of long noncoding RNAs in Chinese patients with pulmonary adenocarcinoma.OncoTargets and therapy · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Recent progress has been made in the identification of protein-coding genes and miRNAs that are expressed in and alter the behavior of colonic epithelia. However, the role of long non-coding RNAs (lncRNAs) in colonic homeostasis is just beginning to be explored. By gene expression profiling of post-mitotic, differentiated tops and proliferative, progenitor-compartment bottoms of microdissected adult mouse colonic crypts, we identified several lncRNAs more highly expressed in crypt bottoms. One identified lncRNA, designated non-coding Nras functional RNA (ncNRFR), resides within the Nras locus but appears to be independent of the Nras coding transcript. Stable overexpression of ncNRFR in non-transformed, conditionally immortalized mouse colonocytes results in malignant transformation, as determined by growth in soft agar and formation of highly invasive tumors in nude mice. Moreover, ncNRFR appears to inhibit the function of the tumor suppressor let-7. These results suggest precise regulation of ncNRFR is necessary for proper cell growth in the colonic crypt, and its misregulation results in neoplastic transformation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.