ArticleDevelopmental cell2013
Autoregulatory feedback controls sequential action of cis-regulatory modules at the brinker locus.
Article in Developmental cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Inferring chromatin architecture at a single locus through probabilistic in situ DNA localization.Nature communications · 2026Article
- Comprehensive Single Molecule View of Transcriptional Dynamics in Development.bioRxiv : the preprint server for biology · 2025Article
- Machine Learning-Driven Prediction of Spatiotemporal Dynamics of Active Nuclei DuringInternational journal of molecular sciences · 2025Article
- Review
- Transcriptional activators in the early Drosophila embryo perform different kinetic roles.Cell systems · 2023Article
- Cell-specific occupancy dynamics between the pioneer-like factor Opa/ZIC and Ocelliless/OTX regulate early head development in embryos.Frontiers in cell and developmental biology · 2023Article
- brinker levels regulated by a promoter proximal element support germ cell homeostasis.Development (Cambridge, England) · 2022Article
- NaNuTrap: a technique for in vivo cell nucleus labelling using nanobodies.Development (Cambridge, England) · 2021Article
- Coacting enhancers can have complementary functions within gene regulatory networks and promote canalization.PLoS genetics · 2019Article
- Distinct Roles of Broadly Expressed Repressors Support Dynamic Enhancer Action and Change in Time.Cell reports · 2019Article
- Article
- The BMP2/4 ortholog Dpp can function as an inter-organ signal that regulates developmental timing.Life science alliance · 2018Article
- Genomic dissection of enhancers uncovers principles of combinatorial regulation and cell type-specific wiring of enhancer-promoter contacts.Nucleic acids research · 2018Article
- Transcriptional precision and accuracy in development: from measurements to models and mechanisms.Development (Cambridge, England) · 2017Review
- Broadly expressed repressors integrate patterning across orthogonal axes in embryos.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Krox20 hindbrain regulation incorporates multiple modes of cooperation between cis-acting elements.PLoS genetics · 2017Article
- Regulatory logic driving stable levels ofDevelopment (Cambridge, England) · 2017Article
- Article
- Stepwise Progression of Embryonic Patterning.Trends in genetics : TIG · 2016Review
- Mitosis-associated repression in development.Genes & development · 2016Article
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4 authors.
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Abstract
cis-regulatory modules (CRMs) act sequentially to regulate temporal expression of genes, but how the switch from one to the next is accomplished is not well understood. To provide insight, here we investigate the cis-regulatory system controlling brinker (brk) expression in the Drosophila embryo. Two distally located CRMs support expression at different times, while a promoter-proximal element (PPE) is required to support their action. In the absence of Brk protein itself or upon mutagenesis of Brk binding sites within the PPE, the late-acting CRM, specifically, is delayed. This block to late-acting CRM function appears to be removed when the early-acting CRM is also deleted. These results demonstrate that autoregulatory feedback is necessary for the early-acting CRM to disengage from the promoter so that the late-acting CRM may act. Autoregulation may be a commonly used mechanism to control sequential CRM action necessary for dynamic gene expression throughout the course of development.
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