ArticleLymphatic research and biology2013
Lymphatic vessel function in head and neck inflammation.
Article in Lymphatic research and biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- From Lymphotoxin to Tertiary Lymphoid Structures and Beyond.Immunological reviews · 2025Review
- Physiology of Glymphatic Solute Transport and Waste Clearance from the Brain.Physiology (Bethesda, Md.) · 2022Review
- Glymphatic Cerebrospinal Fluid and Solute Transport Quantified by MRI and PET Imaging.Neuroscience · 2021Review
- The Hepatic Lymphatic Vascular System: Structure, Function, Markers, and Lymphangiogenesis.Cellular and molecular gastroenterology and hepatology · 2016Review
- High Endothelial Venules and Lymphatic Vessels in Tertiary Lymphoid Organs: Characteristics, Functions, and Regulation.Frontiers in immunology · 2016Review
- A zebrafish model of inflammatory lymphangiogenesis.Biology open · 2015Article
- Article
- The chemokine receptors ACKR2 and CCR2 reciprocally regulate lymphatic vessel density.The EMBO journal · 2014Article
- Lymphotoxin and TNF: how it all began-a tribute to the travelers.Cytokine & growth factor reviews · 2014Review
- The Brain's Waste-Removal System.Cerebrum : the Dana forum on brain scienceArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundSerious infections of the head and neck cause lymphedema that can lead to airway compromise and oropharyngeal obstruction. Lymphangiogenesis occurs in the head and neck during infection and after immunization. The goal of this project was to develop tools to image lymphatic vessels in living animals and to be able to isolate individual lymphatic endothelial cells in order to quantify changes in single cells caused by inflammation.
methodsThe ProxTom transgenic red-fluorescent reporter mouse was developed specifically for the purpose of imaging lymphatic vessels in vivo. Prox1 is a transcription factor that is necessary for lymphangiogenesis in development and for the maintenance of lymphatics in adulthood. Mice were immunized and their lymphatic vessels in lymph nodes were imaged in vivo. Individual lymphatic endothelial cells were isolated by means of their fluorescence.
resultsThe ProxTom transgene has the red-fluorescent reporter td-Tomato under the control of Prox1 regulatory elements. tdTomato was faithfully expressed in lymphatic vessels coincident with endogenous Prox1 expression. We show lymphangiogenesis in vivo after immunization and demonstrate a method for the isolation of lymphatic endothelial cells by their tdTomato red-fluorescence.
conclusionsThe faithful expression of the red-fluorescent reporter in the lymphatic vessels of ProxTom means that these mice have proven utility for in vivo study of lymphatic vessels in the immune response. ProxTom has been made available for distribution from the Jackson Laboratory: http://jaxmice.jax.org/strain/018128.html .
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.