ArticleReproductive biology and endocrinology : RB&E2013
Embryonic diapause in humans: time to consider?
Article in Reproductive biology and endocrinology : RB&E, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 26 citations in OpenAlex.
- Epigenetic mechanisms in maternal-fetal crosstalk: inter- and trans-generational inheritance.Epigenomics · 2025Review
- Using diapause as a platform to understand the biology of dormancy.Open biology · 2025Review
- Matching the green wave: growing season length determines embryonic diapause in roe deer.Proceedings. Biological sciences · 2025Article
- Article
- The molecular mechanisms of diapause and diapause-like reversible arrest.Biochemical Society transactions · 2023Review
- The life cycle of polyploid giant cancer cells and dormancy in cancer: Opportunities for novel therapeutic interventions.Seminars in cancer biology · 2022Review
- Transcriptomics of diapause in an isogenic self-fertilizing vertebrate.BMC genomics · 2015Article
- Molecular and cellular regulators of embryo implantation and their application in improving the implantation potential of IVF-derived blastocysts.Reproductive medicine and biologyReview
- Upregulation of iNOS and phosphorylated eNOS in the implantation-induced blastocysts of mice.Reproductive medicine and biologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundWhen a competent blastocyst stage embryo finds itself in an unreceptive uterus, it delays development. In around one hundred species representing various orders, this delay is known to be reversible, but this phenomenon - termed embryonic diapause (ED) - is not considered a general characteristic of all mammals. PRESENTATION OF THE HYPOTHESIS: Recently, however, we demonstrated that a non-diapausing species, the sheep, is capable of ED, suggesting the hypothesis that this is in fact an ancestral trait common to all mammals, including humans. TESTING THE HYPOTHESIS: In spite of the obvious difficulties in testing this idea, we propose a combination of indirect observations on human fertility patients, and direct study of the embryos of non-human primates. IMPLICATIONS OF THE HYPOTHESIS: Support for our hypothesis would require revision of obstetric interventions routinely performed when a human pregnancy extends beyond the due date.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.