ArticleThe International journal of neuroscience2014
Triallelic relationships between the serotonin transporter polymorphism and cognition among healthy older adults.
Article in The International journal of neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 4 citations in OpenAlex.
- Effect of Gender, Physical Activity and Stress-Related Hormones on Adolescent's Academic Achievements.International journal of environmental research and public health · 2020Article
- Genetic markers of cholesterol transport and gray matter diffusion: a preliminary study of the CETP I405V polymorphism.Journal of neural transmission (Vienna, Austria : 1996) · 2015Article
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9 authors at 3 institutions in 1 country.
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Abstract
The biallelic serotonin transporter polymorphism (5-hydroxytryptamine transporter linked polymorphic region (5-HTTLPR)) is a common genetic sequence associated with serotonin transporter (5-hydroxytryptamine transporter (5-HTT)) expression, which is further modulated by a triallelic single-nucleotide polymorphism (rs25531). Recent studies using the biallelic 5-HTTLPR have identified a beneficial role of low 5-HTT expression on cognitive performance, although no studies have examined the impact of the triallelic 5-HTTLPR/rs25531 marker on cognitive performance among healthy older adults. In the present study, we addressed this issue in 84 healthy older adults genotyped for biallelic and triallelic variants of 5-HTT. Groups were created based on low, medium and high levels of expression, as indicated by the triallelic marker. Results indicated that individuals with low 5-HTT expression performed significantly better on a test of memory compared with individuals with medium 5-HTT expression. This suggests that possession of low-expressing genetic variants of 5-HTT is modestly associated with enhanced cognitive performance among healthy older adults.
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