ArticleJournal of medicinal chemistry2013
Gd-labeled glycol chitosan as a pH-responsive magnetic resonance imaging agent for detecting acidic tumor microenvironments.
Article in Journal of medicinal chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 29 citations in OpenAlex.
- Surface-Charge-Switchable Nanoclusters for Magnetic Resonance Imaging-Guided and Glutathione Depletion-Enhanced Photodynamic Therapy.ACS nano · 2020Article
- Tumor-acidity activated surface charge conversion of two-photon fluorescent nanoprobe for enhanced cellular uptake and targeted imaging of intracellular hydrogen peroxide.Chemical science · 2019Article
- Multicomponent, Tumor-Homing Chitosan Nanoparticles for Cancer Imaging and Therapy.International journal of molecular sciences · 2017Review
- Imaging the Tumor Microenvironment.Advances in experimental medicine and biology · 2017Review
- Novel pH-Sensitive Cyclic Peptides.Scientific reports · 2016Article
- A simple method for the synthesis of porous polymeric vesicles and their application as MR contrast agents.Journal of materials chemistry. B · 2015Article
- A pH-Responsive Drug-Delivery Platform Based on Glycol Chitosan-Coated Liposomes.Small (Weinheim an der Bergstrasse, Germany) · 2015Article
- The pH low insertion peptide pHLIP Variant 3 as a novel marker of acidic malignant lesions.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- A "Smart" ¹²⁸Xe NMR Biosensor for pH-Dependent Cell Labeling.Journal of the American Chemical Society · 2015Article
- Monitoring phospholipase A₂ activity with Gd-encapsulated phospholipid liposomes.Scientific reports · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Neoplastic lesions can create a hostile tumor microenvironment with low extracellular pH. It is commonly believed that these conditions can contribute to tumor progression as well as resistance to therapy. We report the development and characterization of a pH-responsive magnetic resonance imaging contrast agent for imaging the acidic tumor microenvironment. The preparation included the conjugation of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid 1-(2,5-dioxo-1-pyrrolidinyl) ester (DOTA-NHS) to the surface of a water-soluble glycol chitosan (GC) polymer, which contains pH-titrable primary amines, followed by gadolinium complexation (GC-NH2-GdDOTA). GC-NH2-GdDOTA had a chelate-to-polymer ratio of approximately1:24 and a molar relaxivity of 9.1 mM(-1) s(-1). GC-NH2-GdDOTA demonstrated pH-dependent cellular association in vitro compared to the control. It also generated a 2.4-fold enhancement in signal in tumor-bearing mice 2 h postinjection. These findings suggest that glycol chitosan coupled with contrast agents can provide important diagnostic information about the tumor microenvironment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.