ArticleThe Malaysian journal of medical sciences : MJMS2013
Frequencies of Cytochrome P450 2B6 and 2C8 Allelic Variants in the Mozambican Population.
Article in The Malaysian journal of medical sciences : MJMS, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
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- Allelic and genotype frequencies of major CYP2B6 polymorphisms in the Pakistani population.Molecular genetics & genomic medicine · 2021Article
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- Frequencies of CYP2B6Genetics research · 2021Article
- Prevalence ofPharmacogenomics and personalized medicine · 2020Article
- The Prevalence ofOsong public health and research perspectives · 2018Article
- Disease burden and the role of pharmacogenomics in African populations.Global health, epidemiology and genomics · 2017Review
- HLA Association with Drug-Induced Adverse Reactions.Journal of immunology research · 2017Review
- Corrections of Frequencies of Cytochrome P450 2B6 and 2C8 Allelic Variants in the Mozambican Population.The Malaysian journal of medical sciences : MJMS · 2016Article
- DL-ADR: a novel deep learning model for classifying genomic variants into adverse drug reactions.BMC medical genomics · 2016Article
- Preemptive Genotyping of CYP2C8 and CYP2C9 Allelic Variants Involved in NSAIDs Metabolism for Sickle Cell Disease Pain Management.Clinical and translational science · 2015Article
- Nevirapine or efavirenz for tuberculosis and HIV coinfected patients: exposure and virological failure relationship.The Journal of antimicrobial chemotherapy · 2015Article
- Cytochrome P450 single nucleotide polymorphisms in an indigenous Tanzanian population: a concern about the metabolism of artemisinin-based combinations.Malaria journal · 2014Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe cytochrome P450 enzymes (CYP) play an important role in the metabolism of many therapeutic agents. The activities of different enzymes exhibit variability in different populations, which causes variations in drug response or toxicity. The CYP2B6 and CYP2C8 enzymes are encoded by polymorphic genes characterised by different single nucleotide polymorphisms (SNPs). Several of these CYP variants are often associated with slow metabolism phenotypes. This study aimed to analyse the frequencies of allelic variants of CYP2B6 and CYP2C8 in the Mozambican population.
methodsUsing a polymerase chain reaction and restriction fragment length polymorphism assay (PCR-RFLP), the frequencies of the allelic variants of CYP2B6 (c.64C>T, c.516G>T, c.777C>A, c.785A>G, c.1459C>T) and CYP2C8 (c.805A>T, c.416G>A, c.1196A>G, c.792C>G) were determined in 360 Mozambican blood donors.
resultsThe frequencies of the allelic variants of the CYP2B6 gene were 0.057, 0.426, 0.0, 0.410, and 0.004. For the CYP2C8 gene, the frequencies of the allelic variants were 0.160, 0.048, 0.0, and 0.005. No significant differences were observed between the gender and geographic distribution of volunteers around the country.
conclusionThe frequencies of the allelic variants of the CYP2B6 and CYP2C8 genes were found to be homogeneously distributed in the Mozambican population and were comparable to other African populations. Further studies are required to explore the impact of these variants on the clinical response (efficacy and toxicity) of drugs, including antimalarials.
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24043992PMC3773348W2154385728What OpenQuestion holds
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