ArticleProceedings of the National Academy of Sciences of the United States of America2013
Inositol polyphosphate multikinase is a transcriptional coactivator required for immediate early gene induction.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- IPMK at the crossroads of cellular signaling in health and disease.FEBS letters · 2026Review
- From Obscurity to Prominence: IPMK's Expanding Role in Cellular Signaling, Physiology, and Disease.Biomolecules · 2025Review
- Loss of Skeletal Muscle Inositol Polyphosphate Multikinase Disrupts Glucose Regulation and Limits Exercise Capacity.International journal of molecular sciences · 2025Article
- Nuclear phosphoinositide signaling promotes YAP/TAZ-TEAD transcriptional activity in breast cancer.The EMBO journal · 2024Article
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- Inositol Polyphosphate Multikinase Signaling: Multifaceted Functions in Health and Disease.Molecules and cells · 2021Review
- Structural analyses of inositol phosphate second messengers bound to signaling effector proteins.Advances in biological regulation · 2020Review
- Inositol polyphosphate multikinase is a metformin target that regulates cell migration.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- IPMK Mediates Activation of ULK Signaling and Transcriptional Regulation of Autophagy Linked to Liver Inflammation and Regeneration.Cell reports · 2019Article
- Inositol polyphosphate multikinase mediates extinction of fear memory.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Genome-wide interaction studies identify sex-specific risk alleles for nonsyndromic orofacial clefts.Genetic epidemiology · 2018Article
- TRPV1 is a physiological regulator of μ-opioid receptors.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Arabidopsis inositol polyphosphate multikinase delays flowering time through mediating transcriptional activation of FLOWERING LOCUS C.Journal of experimental botany · 2017Article
- The Expanding Significance of Inositol Polyphosphate Multikinase as a Signaling Hub.Molecules and cells · 2017Review
- Inositol phosphate multikinase dependent transcriptional control.Advances in biological regulation · 2017Article
- Inositol polyphosphate multikinase promotes Toll-like receptor-induced inflammation by stabilizing TRAF6.Science advances · 2017Article
- Article
- Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease.JAMA neurology · 2016Article
- Insights into the activation mechanism of class I HDAC complexes by inositol phosphates.Nature communications · 2016Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Profound induction of immediate early genes (IEGs) by neural activation is a critical determinant for plasticity in the brain, but intervening molecular signals are not well characterized. We demonstrate that inositol polyphosphate multikinase (IPMK) acts noncatalytically as a transcriptional coactivator to mediate induction of numerous IEGs. IEG induction by electroconvulsive stimulation is virtually abolished in the brains of IPMK-deleted mice, which also display deficits in spatial memory. Neural activity stimulates binding of IPMK to the histone acetyltransferase CBP and enhances its recruitment to IEG promoters. Interestingly, IPMK regulation of CBP recruitment and IEG induction does not require its catalytic activities. Dominant-negative constructs, which prevent IPMK-CBP binding, substantially decrease IEG induction. As IPMK is ubiquitously expressed, its epigenetic regulation of IEGs may influence diverse nonneural and neural biologic processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.